Clinical trial · Observational
The Asymmetry Distribution of Endometriotic Lesions: Italian Multicenter Study
The Asymmetry of Endometriotic Lesions as Demonstration of the Theory of Menstrual Reflux and Anatomical Niches: Italian Multicenter Study by the ETIC Group
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to understand whether endometriosis lesions - and tumors that can arise in association with endometriosis - occur more often on one side of the pelvis than the other. During surgery, doctors will record the exact location of each lesion to see if there is a consistent right- or left-sided pattern. Understanding these patterns may help improve knowledge about how endometriosis develops (pathogenesis), and thus improve its treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analyze the Laterality of Endometriotic Lesions and Endometriosis-related Tumors | — | UNRESOLVED | — |
| Endometriosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Asymmetric distribution of endometriotic lesions on paired pelvic organs
- timeFrame
- At the time of index surgery
- description
- Proportion of patients presenting an asymmetric (right- or left-sided) distribution of endometriotic lesions on even and symmetrical pelvic organs (e.g., ovaries, uterosacral ligaments), based on the laterality observed and described during the index surgical procedure. Side-specific frequencies (right vs left) will be reported as number and percentage.
Secondary outcomes (1)
- measure
- Asymmetric distribution of malignant ovarian lesions related to endometriosis
- timeFrame
- At the time of index surgery
- description
- Proportion of patients presenting an asymmetric (right- or left-sided) distribution of malignant lesions related to endometriosis-specifically endometrioid ovarian carcinoma, clear cell ovarian carcinoma, and seromucinous borderline tumors-based on the laterality observed and described during the index surgical procedure. Side-specific frequencies (right vs left) will be reported as number and percentage.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥18 years at the time of histological diagnosis of endometriosis * patients undergoing surgery with endometriotic lesions or patients with endometriotic lesions associated with endometrioid or clear cell ovarian cancer (Stage I-II) or borderline seromucinous ovarian cancer * first operation for endometriosis in the reference center (if recurrence consider only if both operations were performed at the reference center). Exclusion Criteria: * age \<18 years * patients affected by Stage I-II endometrioid or clear cell carcinoma or seromucinous borderline ovarian cancer not associated with endometriosis or in a more advanced stage of disease * women with an ultrasound diagnosis of endometriosis who have not undergone surgery * previous operations for endometriosis performed at another center
References
Publications (0)
Data not yet available