Clinical trial · Interventional
Overcoming Barriers to Uptake of Cascade Screening
Let's Talk: Overcoming Barriers to Uptake of Cascade Screening Through a Stakeholder-informed Online Intervention
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lynch syndrome is a genetic condition that increases cancer risk. The public health impact of genetic testing for disease prevention hinges on cascade screening, which is the systematic identification and testing of blood relatives after a family member has been diagnosed with a genetic condition. Despite its importance in disease prevention, only half of first-degree relatives of individuals with Lynch syndrome undergo cascade screening. To address this gap, the study will pilot test an online version of Let's Talk, a novel intervention designed to support and promote cascade screening. This intervention tool is designed to support and encourage more family members to get screened. The purpose of this study aim is to assess the feasibility of the online Let's Talk tool in clinical use by examining implementation and effectiveness outcomes related to the use of the planning tool across three clinics at a large academic-affiliated medical center with patients (n=15) seen by one of five genetic counselors (n=5).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lynch Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Let's Talk Genetics Providers | Behavioral | — | UNRESOLVED |
| Let's Talk Patients | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Genetic Counselor participants
- description
- Participants who are practicing genetic counselor at a medical institution.
- interventionNames
- Behavioral: Let's Talk Genetics Providers
- type
- EXPERIMENTAL
- label
- Patient participants
- description
- Participants who are with diagnosis of Lynch syndrome.
- interventionNames
- Behavioral: Let's Talk Patients
Primary outcomes (1)
- measure
- Change in patient knowledge
- timeFrame
- 2 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria for Patients * Written informed consent obtained to participate in the study. * Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee. * Age ≥ 18 years at the time of consent. * Written informed consent obtained to participate in the study. * Self-reported Lynch syndrome diagnosis. Inclusion Criteria for Genetic Counselor * Written informed consent obtained to participate in the study. * Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee. * Age ≥ 18 years at the time of consent. * Written informed consent obtained to participate in the study. * Self-reported employment as a practicing genetic counselor at a medical institution. Exclusion Criteria for Patients * The patient has already notified all relatives about their diagnosis with Lynch syndrome. Exclusion Criteria for Genetic Counselor * Genetic Counselor is not employed.
References
Publications (0)
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