Clinical trial · Observational
Long-Term Survival With Lenvatinib-Based Therapy in Unresectable Liver Cancer
Long-term Survival of Unresectable Hepatocellular Carcinoma Patients Receiving Lenvatinib-based Therapy: A Retrospective, Multicenter Propensity Score Matching Study
NCT07298538CI-TRIAL-00099568active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study reviewed real-world outcomes of patients with unresectable hepatocellular carcinoma who received lenvatinib-based treatment. The study evaluated long-term survival, treatment response, and safety using data collected from six hospitals.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Unresectable Hepatocellular Carcinoma | Hepatocellular Carcinoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Lenvatinib-based therapy
- label
- Non-lenvatinib therapy
Primary outcomes (1)
- measure
- 3-year Overall Survival Rate Estimated by Kaplan-Meier Method
- timeFrame
- 3 years after treatment initiation
- description
- 3-year cumulative survival rate estimated based on the Kaplan-Meier method
Secondary outcomes (5)
- measure
- Overall survival (OS)
- timeFrame
- Up to 5 years after treatment initiation
- description
- The time interval from treatment initiation to the date of death due to any cause
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * ≥ 18 years of age * Patients with histologically or radiologically confirmed HCC who were newly diagnosed between January 2019 and December 2022 (meeting the diagnostic criteria of the American Association for the Study of Liver Diseases or the Chinese Guidelines for the Diagnosis and Treatment of Primary Liver Cancer). * Patients with at least 1 measurable lesion in the liver per RECIST v.1.1. * Initially unresectable HCC as determined by the investigator (including oncologically unresectable, surgically unresectable, or both). * Child Pugh score ≤ 7 * ECOG-PS 0-1 * Patients who had not received any previous systemic therapy before receiving dual therapy (lenvatinib + immunotherapy/local therapy) or triple therapy (lenvatinib + immunotherapy + local therapy) as the first-line therapy. Combination therapy is defined as the initiation of immunotherapy or local therapy within 30 days (before or after) of the first dose of lenvatinib. * Patients who had basic image data (CT/MRI/PET) and underwent at least one imaging evaluation during the systemic therapy (if the image data was obtained from other hospitals, the original data shall be provided for re-evaluation). Exclusion Criteria: * Patients with no overall survival (OS) endpoint observed, and a follow-up period after treatment initiation of less than 6 months. * Patients with a pathological diagnosis of combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC), cholangiocarcinoma, or other non-HCC malignant tumors. * Patients with other inadequately treated malignant tumors previously or currently. * Prior liver transplantation/hepatectomy/ablation for liver cancer.
References
Publications (0)
Data not yet available
No reference posted for this study.