Clinical trial · Interventional
Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection
NCT07279792CI-TRIAL-00099766completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial will evaluate the efficacy of three bladder irrigation solutions - distilled water (DW), normal saline (NS), and hypertonic saline (HS) - as continuous bladder irrigation (CBI) following transurethral resection of non-muscle invasive bladder cancer (NMIBC). Short term (6 months) recurrence and progression free survival are mainly evaluated.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder (Urothelial, Transitional Cell) Cancer | — | UNRESOLVED | — |
| Distilled Water | — | UNRESOLVED | — |
| Hypertonic Saline | — | UNRESOLVED | — |
| Irrigation | — | UNRESOLVED | — |
| Nonmuscle Invasive Bladder Cancer | — | UNRESOLVED | — |
| Normal Saline | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Continuous Bladder Irrigation with distilled water | Drug | — | UNRESOLVED |
| Continuous Bladder Irrigation with hypertonic saline | Drug | — | UNRESOLVED |
| Continuous Bladder Irrigation with normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Continuous Bladder Irrigation with distilled water
- interventionNames
- Drug: Continuous Bladder Irrigation with distilled water
- type
- ACTIVE_COMPARATOR
- label
- Continuous Bladder Irrigation with normal saline
- interventionNames
- Drug: Continuous Bladder Irrigation with normal saline
- type
- ACTIVE_COMPARATOR
- label
- Continuous Bladder Irrigation with hypertonic saline
- interventionNames
- Drug: Continuous Bladder Irrigation with hypertonic saline
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients of non-muscle invasive urinary bladder urothelial carcinoma amenable for complete resection Exclusion Criteria: * Patients with post-operative complications that need prolonged irrigation. * Patient who underwent incomplete resection during TURBT. * When large bladder perforation was suspected during TURBT. * Patients with chronic kidney disease. * Muscle invasive disease
References
Publications (0)
Data not yet available
No reference posted for this study.