Clinical trial · Interventional
Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid
Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid: A Prospective, Multicenter, Open-Label, Randomized Controlled Trial.
NCT07274605CI-TRIAL-00098728not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy + Central Neck Dissection (reference group).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thymectomy | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extended isthmusectomy | Procedure | — | UNRESOLVED |
| Total thyroidectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Total thyroidectomy
- description
- Patients randomised to this arm will undergo total thyroidectomy with bilateral central compartment (level VI) neck dissection
- interventionNames
- Procedure: Total thyroidectomy
- type
- EXPERIMENTAL
- label
- extended isthmusectomy
- description
- Patients randomised to this arm will undergo extended isthmusectomy (ensure R0 resection) with bilateral central compartment (level VI) neck dissection
- interventionNames
- Procedure: Extended isthmusectomy
Primary outcomes (1)
- measure
- Rate of 3-year recurrence
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: \- Age 18 years or older. Diagnosis of low-risk differentiated thyroid cancer (papillary, follicular, or Hürthle cell carcinoma). Unifocal tumor located in the thyroid isthmus, cT1b No evidence of extrathyroidal extension, assessed by preoperative ultrasound. Exclusion Criteria: \- Aggressive pathological subtypes (e.g., tall cell, clear cell, columnar cell, or diffuse sclerosing variants of papillary thyroid carcinoma, as well as poorly differentiated types). cN1b. M1 Combined with other suspicious thyroid nodules within the lobes.
References
Publications (0)
Data not yet available
No reference posted for this study.