Active Anti-diabetic Treatment Plus Chemotherapy for Pancreatic Cancer Related Diabetes

Inclusion Criteria:

* Ability to understand and the willingness to sign a written informed consent document.
* Age ≥ 18 years and ≤ 80 years.
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
* Histologically or cytologically confirmed metastatic pancreas adenocarcinoma.
* History of diabetes mellitus, or newly diagnosed diabetes meeting the diagnostic criteria of the American Diabetes Association.
* The expected survival ≥ 3 months.
* Able to comply with study visit schedules and other protocol requirements.

Exclusion Criteria:

* • History of other malignancies requiring anti-cancer therapy within 2 years prior to enrollment (except treated Stage I prostate cancer, in situ cervical cancer, in situ breast cancer, etc.);

  * Non-primary pancreatic cancer patients;
  * Digestive tract inflammation, including biliary tract infection, gastrointestinal infection, pancreatitis, etc.;
  * Pregnant or lactating women.