Clinical trial · Interventional
Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma
Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma: A Phase III Randomized Non-Inferiority Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study will evaluate whether omitting Level Va irradiation in patients without these risk features does not compromise regional control or survival, with the goal of providing robust evidence to guide further personalization of NPC radiotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nasopharyngeal Carcinoma by AJCC V9 Stage | Nasopharyngeal Carcinoma by AJCC v9 Stage | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Omission of Level Va Irradiation in Nasopharyngeal Carcinoma | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- level Va-sparing IMRT
- description
- Level Va irradiation is omitted except in the presence of any of the following high-risk features: 1. Ipsilateral Level IIb involvement; 2. Ipsilateral Level III nodes involvement; 3. Ipsilateral positive lymph nodes below the cricoid cartilage (Level IV or Vb-c);
- interventionNames
- Radiation: Omission of Level Va Irradiation in Nasopharyngeal Carcinoma
- type
- NO_INTERVENTION
- label
- level Va-covering IMRT
- description
- Level Va is routinely irradiated according to CACA/CMDA guidelines.
Primary outcomes (1)
- measure
- Regional failure-free survival
- timeFrame
- 3 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pathologic diagnosis (pathologically confirmed by nasopharyngeal biopsy) was nasopharyngeal carcinoma; 2. No distant metastatic; 3. Eastern Cooperative Oncology Group (ECOG) score of 0 or 1; 4. Signing informed consent; 5. Follow up regularly and comply with test requirements. Exclusion Criteria: 1. Ipsilateral Level IIb involvement; 2. Ipsilateral Level III nodes involvement; 3. Ipsilateral positive lymph nodes below the cricoid cartilage (Level IV or Vb-c); 4. Disease progression during IMRT; 5. Previous malignancy or other concomitant malignant diseases; 6. The evaluation information of tumor efficacy can not be obtained; 7. Receive blind treatment in other clinical research; 8. Have or are suffering from other malignant tumors within 5 years (except non- melanoma skin cancer or pre-invasive cervical cancer); 9. Serious complications, such as uncontrolled hypertension, coronary heart disease, diabetes, heart failure, etc; 10. Active systemic infection; 11. No or limited capacity for civil conduct; 12. The patient has a physical or mental disorder, and the researcher considers that the patient is unable to fully or fully understand the possible complications of this study; 13. Pregnancy or lactation period;
References
Publications (0)
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