Clinical trial · Observational
Distribution Characteristics of Helicobacter Pylori
Distribution Characteristics of Helicobacter Pylori in Different Gastritis and Early Gastric Cancer States Using Immunohistochemical Staining
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aimed to analyze the distribution characteristics of Helicobacter pylori（H. pylori） in varying stages of atrophic gastritis and early gastric cancer using immunohistochemical staining, with the goal of providing guidance for the early screening of gastric cancer. A retrospective analysis was conducted on gastric biopsy cases that underwent H. pylori immunohistochemical staining at our center from March 1, 2023, to August 15, 2025. Cases were classified into non-atrophic and atrophic groups based on the presence or absence of gastric atrophy. All cases were further divided into non-open and open atrophy groups and additionally into early gastric cancer and non-cancer groups. The distribution of H. pylori across subgroups was compared, and multivariate analyses were performed to identify risk factors associated with the development of early gastric cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Early Gastric Cancer | Early Gastric Carcinoma | ALIAS | 0.90 |
| Helicobacter Pylori | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| immunohistochemical testing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- received H. pylori immunohistochemical testing at our center and tested positive
- interventionNames
- Diagnostic Test: immunohistochemical testing
Primary outcomes (1)
- measure
- The status of Helicobacter pylori(H. pylori)
- timeFrame
- one week after the endoscopic submucosal dissection (ESD)
- description
- The status of H. pylori included negative and positive status. Positve results were graded as mild (1+): occasional bacteria or colonization in \<1/3 of the specimen length; moderate (2+): colonization exceeding 1/3 but \<2/3 of the specimen, or continuous but sparse distribution on the epithelial surface; and severe (3+): clusters of H. pylori distributed across the full length of the specimen. The gastric body and antrum were assessed separately.
Secondary outcomes (1)
- measure
- the percentage of H. pylori positive status of gastric antrum in early gastric cancer
- timeFrame
- one year after the endoscopic submucosal dissection (ESD)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * age 18-80 years * received H. pylori immunohistochemical testing at our center and tested positive. Exclusion Criteria: * biopsies not collected from both the greater and lesser curvatures of the gastric antrum and body * history of stomach surgery * suspected autoimmune gastritis under endoscopy * liver cirrhosis * severe comorbidities such as advanced cancer or renal failure * advanced gastric cancer or gastric lymphoma
References
Publications (0)
Data not yet available