Clinical trial · Interventional
Non-invasive Characterisation of Oral Carcinomas in Patients With Fanconi Anaemia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with Fanconi anaemia have an increased risk of developing squamous cell carcinoma of the head and neck. In addition, their genetic vulnerability limits the use of genotoxic treatments such as radiotherapy and chemotherapy, due to increased exposure to severe toxicities. Less invasive diagnostic techniques, such as brush biopsies, which rely on cytological and ploidy analysis, offer the possibility of more systematic, comprehensive and less painful oral mapping, thereby facilitating earlier diagnosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fanconi Anaemia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oral brushing | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients with Fanconi anaemia
- interventionNames
- Other: Oral brushing
Primary outcomes (1)
- measure
- Oral brushing
- timeFrame
- Day 0
- description
- * "Positive" result: presence of dysplastic cells at the moderate dysplasia stage or malignant cells. * "Negative" result: absence of dysplastic cells beyond the mild dysplasia stage and absence of malignant cells.
Secondary outcomes (1)
- measure
- oral lesion biopsy
- timeFrame
- Day 0
- description
- * "Positive" result: presence of dysplastic cells at the moderate dysplasia stage or malignant cells. * "Negative" result: absence of dysplastic cells beyond the mild dysplasia stage and absence of malignant cells.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * have Fanconi anaemia * are aged 15 years or older * have at least one oral lesion with or without warning signs * who agree to participate in the study Exclusion Criteria: * pregnant and breastfeeding women * protected by law (guardianship, curatorship, judicial protection) * refusing to participate in the study
References
Publications (0)
Data not yet available