Clinical trial · Interventional
Margin Intraoperative CT Feedback Feedback Study
Efficacy of Intraoperative CT Feedback of Wedge Resected Lung for the Assessment of Surgical Margin
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To date, there is no established method for confirming whether sufficient margins have been obtained during surgery, only post-surgery by a pathologist. The purpose of this study is to evaluate the impact of intraoperative CT margin feedback on surgical decisions, such as additional removal. The ability to accurately evaluate surgical margins intraoperatively could reduce the risk of locoregional recurrence and eliminate the need for additional treatment after surgery. Moreover, optimal intraoperative feedback to surgeon could influence surgical decision making and contribute to the satisfactory outcome. This is a single center clinical trial. A total of 80 patients scheduled for wedge resections for lung malignancies (including suspected patients) will be enrolled in this study. Nine surgeons in the division of thoracic surgery will also be involved as participants. Once the wedge resection is performed, the resected specimen will be inflated and scanned by CT to measure surgical margin intraoperatively. Surgeons will have access to the CT data and the associated margin data immediately. They then may decide if an additional resection is required. The expected margin surveyed by questionnaire will be compared to CT measured margin, and CT measured margin will be compared to pathological margin questionnaires over course. After the total course of surgery, surgeons will be asked to complete a questionnaire as well to assess the satisfaction by intraoperative feedback.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer (Diagnosis) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intraoperative CT of resected lung | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Intraoperative CT of resected lung
- interventionNames
- Other: Intraoperative CT of resected lung
Primary outcomes (1)
- measure
- The contribution of intraoperative feedback to treatment decision, and its validity
- timeFrame
- 2 years
- description
- After the total course of surgery, we will ask each surgeon individually for questionnaire 3 after feedback of the individual result of this study to assess the satisfaction by intraoperative feedback.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients scheduled for wedge resection for lung malignancies (included suspected lesions). * 18 years of age or older. Exclusion Criteria: * Any patients with inability to give informed consent * Wedge resection for non-therapeutic purpose, e.g. diagnostic purpose.
References
Publications (1)
- DERIVEDYanagihara T, Miura K, Bernards N, Kitazawa S, Yokote F, Nakahashi K, Fujibayashi Y, Hinokuma H, Sonoda D, Hayama N, Wakeam E, Donahoe L, Yeung J, Cypel M, De Perrot M, Pierre A, Waddell T, Keshavjee S, Cabanero M, Sato Y, Yasufuku K. Utility of Computed Tomography-Based Intraoperative Surgical Margin Evaluation in Wedge-Resected Lung Specimens. Eur J Cardiothorac Surg. 2026 Feb 5;68(2):ezag074. doi: 10.1093/ejcts/ezag074. PMID 41663896