A Study of Sirolimus (Albumin-Bound) in Combination With Different ADCs Treatment of Advanced Solid Tumors

Inclusion Criteria:

* 1\. Subjects aged 18 to 75 years (inclusive).
* 2\. Patients with advanced solid tumors that are unresectable or metastatic and confirmed by histology or cytology.
* 3\. At least one measurable lesion, as defined by RECIST 1.1 criteria.
* 4\. ECOG performance status of 0 or 1.
* 5\. Expected survival ≥ 3 months.
* 6\. Adequate function of major organs and bone marrow.
* 7\. Willing to provide samples of previously removed tumors or undergo fresh tumor biopsy.
* 8\. Women or man of childbearing potential must use highly effective contraception.
* 9\. Able to understand and voluntarily sign the written informed consent form (ICF).

Exclusion Criteria:

* 1\. Previous use of antibody-conjugated drugs with similar loading agents for treatment.
* 2\. Previous anti-tumor treatment drugs were not adequately removed.
* 3\. Active leptomeningeal disease or uncontrolled CNS metastasis.
* 4\. Having a history of severe or uncontrolled cardiovascular or cerebrovascular diseases.
* 5\. Previous interstitial lung disease requiring glucocorticoid treatment, Or currently suffering from interstitial lung disease/non-infectious pneumonia, or the imaging examination during the screening period cannot rule out interstitial pneumonia/lung disease.
* 6\. Patients who developed severe and moderately severe lung diseases that significantly affected lung function within 6 months of the first medication administration; patients requiring supplementary oxygen therapy.
* 7\. Individuals who currently have eye diseases such as corneal disorders, retinal disorders, or active ocular infections that require intervention, or who have a history of serious corneal-related eye diseases in the past; or who are unwilling to stop wearing corneal contact lenses during the study; or who have other existing eye diseases that affect the assessment of ocular toxicity after the administration of the investigational drug.
* 8\. Currently suffering from skin diseases that require oral or intravenous medication treatment.
* 9\. Had a history of ulcerative colitis or Crohn's disease.
* 10\. Within 14 days prior to the first administration of the medication, there is a need for systemic antibacterial, antifungal or antiviral treatment for severe chronic or active infections, and there is no cure for active tuberculosis.
* 11\. Known to be allergic to any component of the test drug, or allergic to the humanized monoclonal antibody product.
* 12\. Participants with poor compliance.