Clinical trial · Interventional
DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy
Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Desflurane + Normal Saline | Drug | — | UNRESOLVED |
| Dexmedetomidine + Desflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention Group
- description
- Arm 1 - Dexmedetomidine + Desflurane (Intervention Group): Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode.
- interventionNames
- Drug: Dexmedetomidine + Desflurane
- type
- PLACEBO_COMPARATOR
- label
- Control Group
- description
- Arm 2 - Desflurane + Normal Saline (Control Group): Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode
- interventionNames
- Drug: Desflurane + Normal Saline
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18-65 years * ASA Physical Status I-II * Elective laparoscopic colectomy * Written informed consent provided Exclusion Criteria: * Severe cardiac, hepatic, or renal disease * COPD or bronchial asthma * Chronic opioid or psychotropic medication use * Atrioventricular block (grade II-III), sick sinus syndrome * Significant intraoperative bleeding or hemodynamic instability
References
Publications (0)
Data not yet available