A Multi-center Retrospective Study of INO Treating B-ALL

Inclusion Criteria:

* Age between ≥16 and ≤80 years at screening, no gender restrictions
* Be diagnosed with B-ALL
* Appropirate organ function, meeting the following criteria:

  1. Aspartate aminotransferase (AST) ≤3 times the upper limit of normal (ULN);
  2. Alanine aminotransferase (ALT) ≤3 times ULN;
  3. Total bilirubin ≤2 times ULN (for patients with Gilbert's syndrome, total bilirubin ≤3.0 times ULN and direct bilirubin ≤1.5 times ULN);
  4. Serum creatinine ≤1.5 times ULN, or creatinine clearance ≥60 mL/min (using the Cockcroft-Gault formula);
  5. Left ventricular ejection fraction (LVEF) ≥50%;

Exclusion Criteria:

* Active infection at screening.
* Any of the following cardiac conditions:

  1. NYHA Class III or IV congestive heart failure;
  2. Severe arrhythmia requiring treatment;
  3. Uncontrolled hypertension or pulmonary hypertension despite standard therapy;
  4. Unstable angina;
  5. Myocardial infarction, bypass surgery, or stent placement within six months before cell retransfusion;
  6. Clinically significant valvular disease;
  7. Other cardiac conditions deemed unsuitable by the investigator;
* History of epilepsy, cerebellar disease, or other active central nervous system disorders;
* History of hypersensitivity to any component of the investigational product.
* Life expectancy of less than three months;
* Other conditions deemed unsuitable for participation in this clinical trial by the investigator.