Clinical trial · Observational
Insulin Resistance Among Hepatitis C Infected Children
Evaluation of Insulin Resistance in Hepatitis C Infected Thalassemia Children and Survivors of Childhood Malignancy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study was to study the occurrence of insulin resistance in hepatitis C virus infected children who were either thalassemic or survivors of childhood malignancy and its correlation to the HCV viral load and other metabolic factors. The main question it aims to answer is: 1. Do children infected with Hepatitis C have a higher incidence of Insulin resistance compared to healthy controls of same age and gender? 2. Is Insulin resistance occurence affected by HCV viral load, blood transfusion frequency, or metabolic factors? Researchers will compare hepatitis c infected children who are either thalassemic or survivors of childhood malignant to healthy age and sex matched controls. Participants will be subjected to: * standardized Questionnaires, * physical examination and * laboratory investigations including liver functions (ALT, AST, Alkaline phosphatase), Prothrombin time, serum ferritin level, albumin, fasting glucose, fasting insulin level and Insulin resistance assessment by HOMA IR calculation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| This Study is to Assess Occurence of Insulin Resistance Among Hepatits C Infected Children Whether Thalassemic or Survivors of Childhood Malignancy | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Patient group included 60 hepatitis C infected children and adolescents
- description
- The patient group included 30 thalassemic patients and 30 malignancy survivors
- label
- Control group of 30 age and sex matched healthy children and adolescents
Primary outcomes (1)
- measure
- The primary outcome measure was to study the occurrence of insulin resistance in hepatitis C virus infected children who were either thalassemic or survivors of childhood malignancy
- timeFrame
- over a period of 6 months
- description
- Insulin resistance was assessed by using Homeostasis Model Assessment (HOMA) index
Secondary outcomes (1)
- measure
- Secondary outcome measure was to assess correlation between insulin resistance and HCV viral load and metabolic parameters.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * hepatitis C virus ribonucleic acid (RNA) positive children, who were following up at the pediatric hematology and oncology clinic Exclusion Criteria: * patients with concurrent active hepatitis B virus infection (positive for hepatitis B surface antigen) or * autoimmune hepatitis, * primary biliary cirrhosis (PBC), * sclerosing cholangitis, * haemochromatosis, * α1-antitrypsin deficiency, * Wilson's disease, * patients with obesity (BMI \> 25), or * Type 2 DM.
References
Publications (0)
Data not yet available