Evaluation of Hemostatic Agents in Partial Nephrectomy

This prospective randomized study aims to evaluate the effect of adjunctive hemostatic agents (FloSeal® and Surgicel®) on perioperative outcomes in patients undergoing partial nephrectomy for localized renal tumors. A total of 150 patients were randomized into three groups: standard parenchymal suturing (Group A), suturing with FloSeal® (Group B), and suturing with Surgicel® (Group C). The study primarily investigates whether hemostatic agents reduce postoperative hemorrhage, urinary leakage, and positive surgical margin rates. Secondary outcomes include renal function change, operative and ischemia times, estimated blood loss, and hospital stay. All surgeries were performed by a single experienced surgeon at Ankara University Urology Department between January 2023 and December 2024.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Patients aged 18 years or older.
* Diagnosed with localized renal mass (clinical stage T1a-T1b) suitable for partial nephrectomy.
* Adequate preoperative renal function to undergo surgery.
* Signed informed consent obtained prior to study enrollment.
* Undergoing open, laparoscopic, or robotic partial nephrectomy performed by the same experienced surgeon.

Exclusion Criteria:

* Patients with solitary kidney or bilateral renal tumors.
* History of previous renal surgery on the same kidney.
* Evidence of metastatic disease or locally advanced (≥T2) renal tumors.
* Coagulopathy, bleeding disorders, or ongoing anticoagulant therapy that cannot be discontinued.
* Active urinary tract infection or systemic infection.
* Known allergy or hypersensitivity to gelatin or oxidized cellulose components.
* Patients who decline participation or withdraw consent.
* Incomplete perioperative data or loss to follow-up.

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