Clinical trial · Interventional
Phase I Trial of pH Resections of GBM at VA
Targeting Infiltrating Glioblastoma Via pH Sensitive Visualization of Tumor and pH Modulation Through Bicarbonate Transporter SLC4A4
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Glioblastoma is an infiltrating tumor that is difficult to visualize in surgery and on standard images. A special pH (acid-base) related magnetic resonance imaging (MRI) has been developed to better see infiltrating tumor. In this safety study, the investigators will carry out increased levels of pH based resections of infiltrating tumor to assess the tolerability in VA populations.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pH MRI based resection of GBM | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- pH Resections
- description
- This is a single arm study so all patients will receive the intervention
- interventionNames
- Procedure: pH MRI based resection of GBM
Primary outcomes (1)
- measure
- Resection related adverse events
- timeFrame
- 1 month
- description
- Safety as described by surgical complication rates by the data safety and monitoring board
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Ability to provide written informed consent * Karnofsky Performance Scale (KPS) of 70 or higher * Suspected, newly diagnosed or recurrent IDH wild type WHO IV glioblastoma presenting as an intra-axial * Expansile contrast-enhancing mass without evidence of metastatic disease Exclusion Criteria: * Diagnostic uncertainty such as history of extracranial malignancy or autoimmune disease * Medical conditions prohibiting anesthesia or surgery * Tumors involving eloquent brain areas as defined by MRI signal * primary motor cortex, primary sensory cortex, sensorimotor fibers, primary language areas, arcuate fasciculus
References
Publications (0)
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