Clinical trial · Interventional
High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgetic | — | UNRESOLVED | — |
| Glucocorticoid | — | UNRESOLVED | — |
| Lung Cancer (NSCLC) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
| Video Assisted Thoracic Surgery (VATS) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexamethasone | Drug | Dexamethasone | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Low dose Dexamethasone (8mg)
- interventionNames
- Drug: Dexamethasone
- type
- ACTIVE_COMPARATOR
- label
- High dose Dexamethasone (1mg/kg)
- interventionNames
- Drug: Dexamethasone
Primary outcomes (1)
- measure
- Pain when coughing on the morning of first postoperative day.
- timeFrame
- Morning of first postoperative day
- description
- The primary endpoint is pain when coughing on the first morning after surgery, measured on the NRS-scale (0-10; where 0 is no pain, and 10 is the worst possible pain).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 year * Able to understand written and spoken Danish language * PCS ≥20 * Signed written informed consent form. * Patient planned to elective VATS lobectomy/segmentectomy Exclusion Criteria: * Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids. * Individuals with diabetes requiring insulin treatment. * Pregnant or breastfeeding patients. * Patients with known allergies to the study drug. * Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection. * Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications. * Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders. * Regular users of opioid medications. * Patients requiring reoperation within the first two postoperative days. * Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my/segmentectomy.
References
Publications (0)
Data not yet available