Clinical trial · Interventional
Clinical Study on the Safety and Efficacy of Umbilical Cord Blood Infusion in Treating Bone Marrow Suppression .
Clinical Study on the Safety and Efficacy of Unrelated Umbilical Cord Blood Infusion in Treating Bone Marrow Suppression After Chemotherapy in Elderly Patients With Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) .
NCT07201233CI-TRIAL-00096121not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The clinical study aims to evaluate the safety and efficacy of umbilical cord blood transfusion in treating bone marrow suppression after chemotherapy in elderly patients with MDS and AML
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Marrow Suppression | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Umbilical cord blood | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Umbilical cord blood
- interventionNames
- Biological: Umbilical cord blood
Primary outcomes (5)
- measure
- Percentage of patients with bone marrow suppression grade < II.
- timeFrame
- Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
- description
- Calculate the percentage of patients with bone marrow suppression grade \< II based on recorded hematological parameters.
- measure
- hematological parameters like hemoglobin level(Hb)
- timeFrame
- Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
- description
- Monitor and record hemoglobin level(g/L), every 2 days in patients, and maintain a record.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * 1\) Ages 60-80 years , gender unlimited; * 2\) Patients clinically diagnosed with MDS or AML; * 3\) Completed chemotherapy and clinically diagnosed with bone marrow suppression grade 2 or above; * 4\) Patients with no severe impairment of liver and kidney function (total bilirubin (TBIL): ≤ 1.5×ULN; ALT or AST: ≤ 2.5×ULN; Alkaline phosphatase: ≤ 3×ULN; Serum creatinine: ≤ 1.5×ULN); * 5\) Normal cardiac function; * 6\) Patients with ECOG 0-2; * 7\) Patients or their families have been informed and voluntarily signed a written informed consent form. Exclusion Criteria: * 1\) Other factors that may cause abnormalities in white blood cells and neutrophils, such as concurrent infections, invasive procedures, etc. * 2)Presence of interstitial lung disease, non-infectious pneumonia, or uncontrolled systemic diseases (such as diabetes, hypertension, pulmonary fibrosis, and acute pneumonia, etc.). Any unstable systemic diseases: including but not limited to unstable angina, cerebrovascular accident or transient ischemic attack (within 6 months prior to screening), myocardial infarction (within 6 months prior to screening), congestive heart failure (New York Heart Association NYHA classification ≥ III,), severe arrhythmias requiring medication, liver, kidney, or metabolic diseases. * 3\) Any other uncontrolled active diseases that may interfere with participation in the trial; * 4\) Concurrent diagnosis of malignant tumors in other organs; * 5\) Concurrent diagnosis of other hematological disorders; * 6\) Inability to understand or comply with the study protocol; * 7\) Individuals deemed unsuitable for participation in this trial by the investigator.
References
Publications (0)
Data not yet available
No reference posted for this study.