Clinical trial · Observational
What is the Impact of TKI on Thyroid Function in CML Patients?
Assessment of Tyrosine Kinase Inhibitors on Thyroid Functions in Patients With Chronic Myeloid Leukemia
NCT07200882CI-TRIAL-00096047not yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Evaluation of the impact of various TKI on thyroid function in patients diagnosed with cml
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukaemia (Chronic) | Leukemia | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- the impact of TKIs on thyroid in patients with Cml
- timeFrame
- 1 year
- description
- To evaluate the impact of TKIs on thyroid in patients with Cml by measuring changes in thyroid hormone levels ( TSH Free T4 Free T3) over time and determining the prevalence of thyroid disorder (hyperthyroidism and hypothyroidism )among tki treated patients
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients age from 18 to 65 year Newly diagnosed CML patients with Philadelphia chromosome positive based on peripheral blood findings and molecular analysis for the BCR-ABL mutation initiating ttt with a TKI (Philadelphia chromosome positive. CML patients ) Exclusion Criteria: * -any history of using drugs interfering with TKI or having effect on thyroid function (Dexamethasone, Phenytoin, Carbamazepine, Rifampin and Phenobarbital) Patients with a history of thyroid disease ( hypo or hyperthyroidism or auto immunity )or are already on treatment for thyroid dysfunction * pregnancy and lactation * concomitant use of oral contraceptive pills or corticosteroids. * Other malignancies requiring concurrent treatment * previous ttt with TKI
References
Publications (0)
Data not yet available
No reference posted for this study.