Clinical trial · Interventional
Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery
Effect of Ultrasound Guided Pecs Block With Intravenous Ketamine and Ketamine Infusion Alone For Prevention of Chronic Post-Surgical Pain in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to is to compare the effectiveness of ultrasound-guided Pecs block with intravenous ketamine versus intravenous ketamine infusion alone in preventing Chronic Post-Surgical Pain (CPSP) in patients undergoing breast cancer surgery. The main question it aims to answer is, How effective is the ketamine and ketamine with pecs block in reducing the frequency of Chronic Post-Surgical Pain after breast cancer surgery
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Pain, Chronic | — | UNRESOLVED | — |
| Post Surgical Pain | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketamine | Drug | — | UNRESOLVED |
| Nalbuphine | Drug | — | UNRESOLVED |
| Paracetamol | Drug | — | UNRESOLVED |
| Pecs block | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Group K
- description
- Intravenous Nalbuphine 0.1 mg/kg Paracetamol 1g or 15mg/kg (if weight is \< 50kg). Additionally, before skin incision, a bolus 0.35 mg/kg ketamine will be given followed by a continuous infusion 0.25 mg/kg/hr (11) will be administered. Ketamine infusion will be stopped 30 minutes before the end of the surgery.
- interventionNames
- Drug: Ketamine
- Drug: Nalbuphine
- Drug: Paracetamol
- type
- EXPERIMENTAL
- label
- Group K+ Pecs
- description
- Intravenous Nalbuphine 0.1 mg/kg Paracetamol 1g or 15mg/kg (if weight is \< 50kg). Additionally, before skin incision, a bolus 0.35 mg/kg ketamine will be given followed by a continuous infusion 0.25 mg/kg/hr (11) will be administered. Ketamine infusion will be stopped 30 minutes before the end of the surgery. Additionally, Pecs block will be performed before surgical incision with the help of an ultrasound (US) by experienced anesthesiologist. The drug used for the pecs block will be two syringes of 10ml and 20 ml containing bupivacaine 0.25% (total 30 ml).
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adult female patients with breast cancer aged between 18-75 years * ASA (American Society of Anesthesia) physical status I, II, and III * Patients scheduled for elective breast cancer surgery (Mastectomy with or without axillary clearance) Exclusion Criteria: * Refusal to participate or withdrawal of informed consent * Surgical procedures involving breast reconstruction with flaps or implants * Patient scheduled for bilateral mastectomy * Reoperation on the same side due to cancer recurrence * Known allergy or contraindication to study drugs * History of severe psychiatric illness (e.g., major depression, bipolar disorder, schizophrenia) * Chronic opioid use, substance abuse, or opioid addiction * Pre-existing chronic pain or neuropathic pain disorders * Coagulopathy, anticoagulation therapy, or localized infection at the site of block * Uncontrolled hypertension and ischemic heart disease
References
Publications (0)
Data not yet available