Clinical trial · Interventional
Study of CM336 in Relapsed or Refractory Multiple Myeloma Patients
A Phase III, Randomized, Open-Label, Multicenter Study Comparing CM336 Monotherapy vs. Investigators Selected Standard of Care in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received ≥2 Prior Lines of Therapy
NCT07181239CI-TRIAL-00095385not yet recruitingPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare the efficacy between CM336 and investigator's choice Standard of Care in relapsed or refractory multiple myeloma (RRMM) patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma (MM) | Multiple Myeloma | CURATED_EXACT | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CM336 Injection | Drug | — | UNRESOLVED |
| Standard Of Care( SOC) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm A: CM336
- interventionNames
- Drug: CM336 Injection
- type
- ACTIVE_COMPARATOR
- label
- Arm B: Standard of Care Regimens
- interventionNames
- Drug: Standard Of Care( SOC)
Primary outcomes (1)
- measure
- PFS
- timeFrame
- Up to 4 years
- description
- The progression-free survival (PFS) evaluated by Blinded Independent Central Review (BICR)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * The subjects voluntarily sign the informed consent form (ICF) and agree to abide by the provisions of this protocol. * Age ≥ 18 years old, gender is not limited. * Eastern Cooperative Oncology Group performance status score (ECOG) 0-2 points. * Patients with relapsed or refractory multiple myeloma who have received at least two lines of anti-myeloma treatment previously, and must include at least one proteasome inhibitor (PI), one immunomodulatory agent (IMiD), and one anti-Cluster of Differentiation 38(CD38) monoclonal antibody. * The subject has evidence of disease progression or has not achieved remission after the last line of treatment, as determined by the investigator based on the International Myeloma Working Group (2016) criteria. * The subject has measurable disease at the screening period, meeting at least one of the following criteria: 1. Serum M protein ≥ 5 g/L; 2. Urinary M protein ≥ 200 mg/24 h; 3. Serum free light chain (sFLC) ≥ 100 mg/L and abnormal κ/ λ ratio. Exclusion Criteria: * Previous receipt of any treatment targeting B-cell maturation antigen (BCMA). * Those who are intolerant to dexamethasone will be excluded. * Within 3 months prior to the first administration, they have received chimeric antigen receptor T cells (CAR-T) /chimeric antigen receptor Nature killer cell (CAR-NK) therapy. * Within 3 months prior to the first administration, they have received autologous stem cell transplantation; within 6 months prior to the first administration, they have received allogeneic stem cell transplantation (for subjects who have received allogeneic transplantation, they must have discontinued all immunosuppressants for ≥ 6 weeks and have no signs of graft-versus-host disease before being eligible for enrollment).
References
Publications (0)
Data not yet available
No reference posted for this study.