Clinical trial · Interventional
Two Cut-Off Values of Plethysmographic Variability Index to Guide Intraoperative Fluid Therapy on Serum Lactate in Patients Undergoing Excision of Supra-Tentorial Brain Tumors
Effect of Two Cut-Off Values of Plethysmographic Variability Index to Guide Intraoperative Fluid Therapy on Serum Lactate in Patients Undergoing Excision of Supra-Tentorial Brain Tumors: A Randomized Controlled Study
NCT07174128CI-TRIAL-00108885completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aimed to compare two cut-off values of plethysmographic variability index (PVI) -guided fluid therapy in patients undergoing supra-tentorial mass excision regarding immediate postoperative serum lactate.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cut-Off Value | — | UNRESOLVED | — |
| Excision | — | UNRESOLVED | — |
| Fluid Therapy | — | UNRESOLVED | — |
| Intraoperative | — | UNRESOLVED | — |
| Plethysmographic Variability Index | — | UNRESOLVED | — |
| Serum Lactate | — | UNRESOLVED | — |
| Supra-Tentorial Brain Tumors | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fluid Therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Low PVI group
- description
- Patients would receive the second round of fluid loading if the Plethysmographic Variability Index (PVI) was 14%.
- interventionNames
- Other: Fluid Therapy
- type
- EXPERIMENTAL
- label
- High PVI gro
- description
- Patients would receive the second round of fluid loading if the Plethysmographic Variability Index (PVI) was 20%.
- interventionNames
- Other: Fluid Therapy
Primary outcomes (1)
- measure
- Serum lactate level
- timeFrame
- 24 hours postoperatively
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age above 18 years old. * Both sexes. * Patients scheduled for supra-tentorial brain tumor excision. Exclusion Criteria: * Arrhythmias. * Pulmonary hypertension. * Impaired cardiac contractility. * Impaired liver or kidney function. * Low lung compliance. * Body mass index above 40. * Intra-operative hemodynamic instability on vasopressors or inotropes. * Peripheral arterial occlusive diseases. * Hand injuries or burns that preclude the application of the Masimo device probe.
References
Publications (0)
Data not yet available
No reference posted for this study.