Clinical trial · Interventional
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG), Randomized Controlled Double-blinded Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG). Intraoperative ECOG has been used in an effort to localize the site of epileptogenicity through the demonstration of Interictal Epileptiform Discharges (IED) persistence, frequency, and distribution. During ECOG, pharmaco-activation may be required in order to activate Interictal Epileptiform Abnormalities (IEAs). Frequency of IEAs will be measured for each drug. The effects of anesthetic agents on intraoperative ECOG, as we assume that fentanyl will be superior to ketamine.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Epilepsy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fentanyl (IV) | Drug | — | UNRESOLVED |
| Ketamine (0.5 mg/kg) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Fentanyl
- description
- fentanyl will be used as bolus (1 µg/kg) for spike stimulation
- interventionNames
- Drug: Fentanyl (IV)
- type
- EXPERIMENTAL
- label
- Ketamine
- description
- ketamine will be used (0.5 mg/kg) for spike stimulation
- interventionNames
- Drug: Ketamine (0.5 mg/kg)
Primary outcomes (3)
- measure
- Effect of fentanyl and ketamine on frequency of spike activation during intraoperative ECOG
- timeFrame
- 18 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 2 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age (2-18) Years scheduled for brain tumor excision with aid of ECOG * ASA physical status (II-III). * Patient undergoing brain surgery with epileptic focus. Exclusion Criteria: * guardian refusal. * Patients with hypertension, ischemic heart disease, arrhythmia, or respiratory or renal dysfunction.
References
Publications (1)
- RESULTLemieux, L., et al. (2012). "Invasive EEG for Epilepsy Surgery: Current Techniques and Considerations." Journal of Clinical Neurophysiology, 29(3), 246-257.