Clinical trial · Observational
Identification of New Non-invasive, Predictive, and Diagnostic Biomarkers for Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study in question is an observational study that aims to identify new non-invasive biomarkers present in the serum of patients with CRC and, subsequently, to create a score capable of predicting the development of CRC. It is an observational study with 3 enrollment arms: Arm 1: Patients undergoing surgery at the U.O.C. of Surgery, with a CRC diagnosis; Arm 2: Subjects with a negative result from the endoscopic examination; Arm 3: Subjects in whom the presence of an adenoma with high-grade dysplasia is found, a condition considered pre-cancerous.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenoma Colon | — | UNRESOLVED | — |
| CRC (Colorectal Cancer) | Colorectal Carcinoma | ALIAS | 0.85 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Patients undergoing surgery at the Department of Surgery, with a diagnosis of CRC;
- description
- Patients undergoing surgery at the Department of Surgery, with a diagnosis of CRC;
- label
- Subjects with a negative endoscopic examination result.
- description
- Subjects who attend our Institution's Department of Digestive Endoscopy for a colonoscopy performed for diagnostic purposes, with a negative endoscopic examination result.
- label
- Subjects with a diagnosis of adenoma with high-grade dysplasia, a condition considered pre-cancerous
- description
- Subjects who attend our Institution's Department of Digestive Endoscopy for a colonoscopy performed for diagnostic purposes, or patients undergoing a surgical procedure at the Department of Surgery, in whom the presence of an adenoma with high-grade dysplasia is found, a condition considered pre-cancerous.
Primary outcomes (1)
- measure
- Variation in serum biomarkers for CRC
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * AIM 1: Patients undergoing surgery at the U.O.C. of Surgery, with a diagnosis of CRC. * AIM 2: Subjects without colon disease. * AIM 3: Subjects with adenoma and high-grade dysplasia. Exclusion Criteria: * Subject with any other pathology not included in the inclusion criteria.
References
Publications (3)
- BACKGROUNDMartin-Garcia D, Garcia-Aranda M, Redondo M. Biomarker Identification through Proteomics in Colorectal Cancer. Int J Mol Sci. 2024 Feb 14;25(4):2283. doi: 10.3390/ijms25042283. PMID 38396959
- BACKGROUNDShah SC, Itzkowitz SH. Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management. Gastroenterology. 2022 Mar;162(3):715-730.e3. doi: 10.1053/j.gastro.2021.10.035. Epub 2021 Oct 29. PMID 34757143
- BACKGROUNDSninsky JA, Shore BM, Lupu GV, Crockett SD. Risk Factors for Colorectal Polyps and Cancer. Gastrointest Endosc Clin N Am. 2022 Apr;32(2):195-213. doi: 10.1016/j.giec.2021.12.008. Epub 2022 Feb 22. PMID 35361331