The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for Colorectal Cancer

Inclusion Criteria:

* Aged 18-70 years;
* No restriction on gender;
* Have completed radical resection for colorectal cancer (including open, laparoscopic, or robotic surgery), and assessed by the MDT as requiring adjuvant therapy primarily based on 5-FU and its derivatives or platinum-based regimens (including chemotherapy, targeted therapy, or radiotherapy);
* ECOG performance status score of 0-2;
* Signed informed consent

Exclusion Criteria:

* Use of probiotics, prebiotics, synbiotics, or antibiotics within 2 weeks prior to enrollment;
* Presence of psychiatric disorders or other conditions that prevent cooperation with the intervention;
* Dysfunction of vital organs such as the liver, kidneys, or heart that renders the individual unsuitable for clinical research upon assessment, or inadequate bone marrow, liver, or renal function to undergo adjuvant therapy;
* Participation in other clinical studies within 3 months prior to enrollment;
* History of inflammatory bowel disease;
* History of autoimmune diseases;
* Pregnancy or breastfeeding;
* Receipt of neoadjuvant therapy (including chemotherapy, radiotherapy, or targeted therapy) prior to surgery;
* Underwent ostomy surgery during the operation (including temporary or permanent ostomy).