Clinical trial · Observational
Volume-Restricted Resection for Perihilar Cholangiocarcinoma
Volume-Restricted Liver Resections for Perihilar Cholangiocarcinoma With Insufficient Future Liver Remnant Volume: A Prospective, Multicenter, Real-World Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn about the safety and long-term outcomes of volume-restricted liver resection in patients with perihilar cholangiocarcinoma (pCCA) who have an insufficient future liver remnant (FLR). The main question it aims to answer is: Does volume-restricted liver resection improve surgical safety and long-term survival compared with standard treatment in pCCA patients with insufficient FLR? Participants with insufficient FLR who undergo volume-restricted liver resection or receive non-surgical treatment as part of their routine medical care will be followed for survival, postoperative complications, and other clinical outcomes. Data from patients with sufficient FLR undergoing standard radical resection will also be collected for comparison.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cholangiocarcinoma, Hilar | Hilar Cholangiocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- From the date of surgery/treatment until death or study termination, approximately 5 years.
- description
- The period from the time when the patient was diagnosed with the disease or began receiving corresponding treatment until his or her death due to any cause.
Secondary outcomes (5)
- measure
- Progression-free survival
- timeFrame
- Disease progression/death
- description
- From the date the patient begins treatment to the date of disease progression or death, whichever occurs first.
- measure
- R0 resection rate
- timeFrame
- Within 7 days after surgery(pathology report)
- description
- The percentage of subjects achieving R0 resection.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with pathologically confirmed hilar cholangiocarcinoma, or those with a high index of clinical suspicion for hilar bile duct malignancy despite the lack of histological confirmation. * Patients who are able to understand and cooperate with this study. * Patients who are able to provide and sign the written informed consent form before undergoing any screening procedures related to the study. Exclusion Criteria: * Patients with preoperatively or intraoperatively confirmed distant metastasis, including peritoneal dissemination, distant lymph node metastasis, hepatic or other organ metastasis. * Patients who underwent palliative surgery only.
References
Publications (0)
Data not yet available