Clinical trial · Interventional
Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
NCT07147270CI-TRIAL-00094276recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
chemical pleurodesis using doxycycline is an acceptable and commonly employed palliation for malignant pleural effusion. Rotation of patient during pleurodesis using the powder from doxycycline capsule is still practiced in some centers. The benefit of rotation practice in pleurodesis can be verified after properly designed study on the outcome of pleurodesis with rotation and non-rotation by chest ultrasound assessment
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Effect of Patient Rotation on Pleurodesis Success and Patient Comfort | — | UNRESOLVED | — |
| Malignant Pleural Effusion | — | UNRESOLVED | — |
| Pleurodesis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| side to side and front to back rotation 30 minutes each | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- no rotation after pleurodesis
- type
- ACTIVE_COMPARATOR
- label
- rotation after pleurodesis
- interventionNames
- Other: side to side and front to back rotation 30 minutes each
Primary outcomes (1)
- measure
- Measurement of pleural adhesion score in patients with malignant pleural effusion candidates for pleurodesis in group with rotation and the other without rotation
- timeFrame
- immediatly and after one month from pleurodesis
- description
- study how patient rotation after pleurodesis affects its success by measuring pleural adherence score by chest ultrasound, a higher adhesion score means successful pleurodesis
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients who will be admitted at Chest department, Ain-Shams University Hospitals with malignant pleural effusions candidate for pleurodesis Exclusion Criteria: * Multiloculated fluid * Previous failed pleurodesis * Liver failure * Renal failure * Congestive heart failure * Prolonged use of steroids or NSAIDs * Refusal to participate
References
Publications (1)
- DERIVEDEzzelregal HG, Abdelsamad AM. Impact of patient positioning on the efficacy and safety of doxycycline pleurodesis in malignant pleural effusion: a pilot randomized trial. BMC Pulm Med. 2026 Aug 31;26(1):384. doi: 10.1186/s12890-026-04630-3. PMID 42669653