Clinical trial · Observational
Prognostic Impacts of Lipid Profile and BMI in Adult AML
Prognostic Impacts of Lipid Profile and Body Mass Index in Adult Acute Myeloid Leukemia Patients Treated With Intensive Induction Chemotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to evaluate the changes in lipid profile parameters (total cholesterol, triglycerides, HDL-C, and LDL-C) in adult AML patients before and after intensive induction chemotherapy. The main questions it aims to answer are: * Are there correlations between metabolic changes (in lipid profile and BMI) and treatment outcomes, including remission status and incidence of chemotherapy-related complications? * Can the baseline lipid profile and BMI serve as prognostic markers for response to induction chemotherapy.? Participants will be observed before and after induction chemotherapy regarding their lipid profile, and BMI, observing any correlations between the different results with any complications, and with remission status.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| AML (Acute Myeloid Leukemia) | Acute Myeloid Leukemia | ALIAS | 0.90 |
| BMI | — | UNRESOLVED | — |
| Induction Chemotherapy | — | UNRESOLVED | — |
| Lipid Profile | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Changes in lipid profile
- timeFrame
- Pre-induction to post-induction (day 28-35).
- description
- Observing changes of lipid profile (total cholesterol, triglycerides, HDL-C, LDL-C) measured at baseline and after completion of induction therapy
- measure
- Changes in Body Mass Index
- timeFrame
- Pre-induction to post-induction (day 28-35)
- description
- Observing changes of Body Mass Index (measured as weight in kilograms divided by squared height in meters) measured at baseline and after completion of induction therapy
Secondary outcomes (2)
- measure
- Association of lipid profile changes with treatment response
- timeFrame
- Pre-induction to post-induction (day 28-35).
- description
- Observing association of lipid profile changes with treatment response (complete remission, partial response, failure), occurrence of treatment-related complications (e.g., infections, tumor lysis syndrome), and duration of hospitalization.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (≥18yearsold) newly diagnosed with AML. * Patients eligible for intensive induction chemotherapy. * Patients who have given informed consent to participate in the study. Exclusion Criteria: * Patients with secondary or relapsed AML. * Patients currently using lipid-lowering medications (e.g., statins). * Patients with known endocrine or metabolic disorders affecting BMI or lipid profile (e.g., uncontrolled diabetes, hypothyroidism, Cushing's syndrome). * Pregnant or lactating women. * Patients unwilling or unable to complete the study protocol. * Patients with M3 subtype of AML.
References
Publications (0)
Data not yet available