Clinical trial · Interventional
Re-Engaging AYA Survivors in Cancer-Related Healthcare
Re-Engaging AYA Survivors in Cancer-Related Healthcare: A Sequential Multiple Assignment Randomized Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to test the efficacy (how well they work) of different digital interventions that deliver information to adolescent and young adult (AYA) survivors of childhood cancer to promote re-engagement in cancer-related long-term follow-up care (LTFU). The main aims are: * To test the efficacy of adaptive interventions (AIs) that begin with low touch intervention (LTI) as compared to written information (WI) on attending an appointment, and self-reported self-management among AYA. * To identify the most efficacious second-stage strategy for those who initially schedule/attend an appointment (maintenance vs. step-up) and for those who do not (step-up vs. step-up maximum). * To assess multilevel factors contributing to the effects of re-engaging AYA and how best to integrate AIs into practice. Throughout the duration of the study, participants will complete four surveys, receive a series of interventions, and may be asked to participate in an interview (post-intervention).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Stage 1 Low Touch Intervention | Behavioral | — | UNRESOLVED |
| Stage 1 Written Information | Behavioral | — | UNRESOLVED |
| Stage 2 High Touch Intervention | Behavioral | — | UNRESOLVED |
| Stage 2 Low Touch Intervention | Behavioral | — | UNRESOLVED |
| Stage 2 Written Information | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (7)
- type
- EXPERIMENTAL
- label
- Written Intervention + Written Intervention (Responders)
- description
- Start with written intervention (WI) in stage 1, those who respond (schedule an appointment) in stage 1 continue receiving WI in stage 2 (maintenance).
- interventionNames
- Behavioral: Stage 1 Written Information
- Behavioral: Stage 2 Written Information
- type
- EXPERIMENTAL
- label
- Written Intervention + Low Touch Intervention (Responders)
- description
- Start with written intervention (WI) in stage 1, those who respond (schedule an appointment) in stage 1, step up to receive low touch intervention (LTI) in stage 2.
- interventionNames
- Behavioral: Stage 1 Written Information
- Behavioral: Stage 2 Low Touch Intervention
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 29 Years
Show eligibility criteria text
Inclusion Criteria for AYA 1. 15-29 years old 2. History of a childhood cancer diagnosis, diagnosed prior to age 22 3. Has not had a cancer-related follow-up visit in at least 15 months (or is 3 months past recommended follow-up) 4. U.S. resident (not international patient) 5. Has previously attended a cancer-related appointment at Children's Hospital of Philadelphia, or Nationwide Children's Hospital or Penn 6. At least 2 years from end of treatment and 5 years from diagnosis 7. English proficient 8. For AYA under age 18, must have a caregiver to provide informed consent Exclusion Criteria for AYA 1. Cognitive impairment limiting participation 2. Received surgery only treatment 3. Transferred to primary care 4. Currently living with cancer diagnosis (either new, metastatic, recurrence, or relapse) 5. Absence of documentation of treatment history 6. Absence of inclusion criteria above Inclusion Criteria for Support Person of AYA 1. Primary caregiver or other support person (e.g. partner, sibling, other caregiver) 2. At least 18 years old 3. U.S. resident 4. English proficient Exclusion Criteria for Support Person of AYA 1. No involvement in the AYA's healthcare 2. AYA Decline support person's participation 3. Absence of inclusion criteria above
References
Publications (0)
Data not yet available