Clinical trial · Observational
EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
Saliva as Early Detection Tool for Oral Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| saliva a a diagnostic tool for early detection of oral cancer | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Normal healthy volunteers
- description
- oral examination will be done, those without any oral infection, oral submucous fibrosis or cancer will be included in health volunteer group
- interventionNames
- Diagnostic Test: saliva a a diagnostic tool for early detection of oral cancer
- label
- oral submucous fibrosis
- description
- Patients with oral submucous fibrosis both with and without limited mouth opening
- interventionNames
- Diagnostic Test: saliva a a diagnostic tool for early detection of oral cancer
- label
- oral cancer patients
- description
- patients with biopsy proven oral cancer
- interventionNames
- Diagnostic Test: saliva a a diagnostic tool for early detection of oral cancer
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * healthy volunteers * patients with oral submucous fibrosis * patients with biopsy proven oral cancer Exclusion Criteria: * patients with oral infection
References
Publications (0)
Data not yet available