Clinical trial · Observational
Validation of RCC Predicting Model With Emulated-target Trial
Emulated-target Trial for Guiding Stratified Treatment for Renal Cell Carcinoma With Venous Tumor Thrombus
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This single-center study utilizes real-world data (2012-2024) from 4700 renal cell carcinoma (RCC) patients at Peking University Third Hospital to: (1) Develop and validate a prognostic prediction model specifically for RCC patients, including those with venous tumor thrombus (VTT); (2) Compare the performance of this new model against existing RCC prediction models in both the overall RCC cohort and the VTT subgroup; (3) Employ an emulated target trial (ETT) methodology to evaluate whether risk-stratified treatment based on the prediction model (grouping patients as high/medium/low risk) improves survival outcomes .
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Observational Study | — | UNRESOLVED | — |
| Prognosis | — | UNRESOLVED | — |
| Prognostic Cancer Model | — | UNRESOLVED | — |
| Real World Study | — | UNRESOLVED | — |
| Renal Cell Carcinoma (Kidney Cancer) | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
| Renal Cell Carcinoma (RCC) | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
| Tumor Thrombus | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Model-guided adjuvant treatment | Procedure | — | UNRESOLVED |
| No adjuvant treatment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- model-stratified group
- description
- Patient receiving treatment in accord with stratified result of the established model.
- interventionNames
- Procedure: Model-guided adjuvant treatment
- label
- non-model-stratified group
- description
- Patient receiving treatment not in accord with stratified result of the established model.
- interventionNames
- Procedure: No adjuvant treatment
Primary outcomes (1)
- measure
- Disease-free Survival
- timeFrame
- From date of follow-up until the date of (1) local or regional recurrence, (2) distant recurrence, (3) second primary cancer, or (4) death from any cause., whichever came first, assessing up to 48 months.
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adults ≥18 years of age; * Diagnosis of primary renal cell carcinoma before and during the surgery; * Received radical nephrectomy/nephron-sparing surgery. Exclusion Criteria: * Subjects with severely missing clinical information; * History of other malignant tumors. * Recurrence observed before first postoperative follow-up. * Discontinue the adjuvant treatment within in the first two course because of severe adverse react.
References
Publications (0)
Data not yet available