Improving Sarcopenia in Cancer Patients Undergoing Chemotherapy With High-Protein Nutritional Supplementation

This study aims to investigate whether a high-protein nutritional supplement (ETHANWELL BALANCED) can help improve muscle strength and reduce fatigue in cancer patients who are at risk of sarcopenia (age- or disease-related muscle loss) during chemotherapy. Sarcopenia is common in older adults and cancer patients and can lead to weakness, poor treatment tolerance, and reduced quality of life. Participants aged 40 and older, receiving chemotherapy, and showing early signs of sarcopenia will be randomly assigned to two groups. The experimental group will receive nutritional education and take a high-protein nutritional drink three times per day for 8 weeks. Both groups will continue their usual medical care and perform simple resistance exercises at home. Researchers will measure changes in grip strength, fatigue, quality of life, and nutritional status over a 12-week period. This study will help determine whether early nutrition intervention can improve treatment outcomes and quality of life for cancer patients with sarcopenia.

Sex

All

Minimum age

40 Years

Inclusion Criteria:

1. Age 40 and above.
2. Patients receiving chemotherapy or expected to undergo thoracic surgery (stage I\~IV)
3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 and SARC-F score ≥ 4.
4. Grip strength: \<28kg for males and \<18kg for females.
5. Conscious and able to communicate.

Exclusion Criteria:

1. Central nervous system disorders and chronic kidney failure.
2. Mental illness or inability to cooperate.
3. Expected survival period less than 3 months.
4. Gastrointestinal dysfunction-patients who have undergone gastric resection surgery or have intestinal obstruction.
5. Heart failure-NYHA class IV.
6. Uncontrollable infection diagnosed by a physician.
7. Poorly controlled diabetes diagnosed by a physician.
8. End-stage renal disease-requiring hemodialysis or peritoneal dialysis.
9. Liver cirrhosis with severe ascites.

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