Clinical trial · Interventional
NB02(POSELTINIB) Monotherapy in R/R Non-Hodgkin's Lymphoma
An Open-Label, Multicenter, Monotherapy, Dose-Escalation, Phase 1 Clinical Trial of NB02 (Posseltinib) in Patients With Relapsed/Refractory Non-Hodgkin's Lymphoma
NCT07114367CI-TRIAL-00102053POTENTIAL-MrecruitingPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial is an open-label, multicenter, monotherapy, dose-escalation, phase 1 clinical trial to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary anti-tumor activity of NB02 (posseltinib) in patients with relapsed/refractory NHL including FL, MCL and MZL
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Hodgkin Lymphoma (NHL) | Non-Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| NB02 (Poseltinib) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- NB02 (Poseltinib)
- description
- Dose Level 1 Dose Level 2 Dose Level 3
- interventionNames
- Drug: NB02 (Poseltinib)
Primary outcomes (2)
- measure
- MTD(maximum tolerated dose) or OBD(optimal biological dose)
- timeFrame
- Approximately 48 Months
- description
- MTD(maximum tolerated dose) or OBD(optimal biological dose)
- measure
- AEs
- timeFrame
- Approximately 48 Months
- description
- AEs
Secondary outcomes (12)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 19 to 80 years. 2. Patients must voluntarily agree to participate in the study and provide written informed consent prior to any study-related procedures. 3. Patients with histologically confirmed follicular lymphoma, mantle cell lymphoma or marginal zone lymphoma. 4. relapsed/refractory Patients who have received more than two prior lines of therapy. 5. Measurable disease based on Lugano classification. 6. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2. 7. Adequate organ function including: Exclusion Criteria: 1. Previous treatment with NB02 (poseltinib). 2. Patients who have experienced progression on BTKi mono or BTKi containing regimen (However, patients who discontinued treatment due to adverse-effect-related intolerance or for economic or social reasons remain eligible for enrollment). 3. Unable to take oral medication. 4. Inability to comply with study and follow-up procedures. 5. Concurrent use of other investigational drugs or enrollment in another clinical trial within 4 weeks prior to study drug administration. 6. Patients who have previously been treated with NB02 (poseltinib) or any other BTK inhibitors (e.g., ibrutinib, acalabrutinib, zanubrutinib). 7. Known HIV, HCV and HBV infection with active diseases
References
Publications (0)
Data not yet available
No reference posted for this study.