Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

This clinical trial studies how the flavors and synthetic coolant properties in oral nicotine pouches (ONPs) compare to one another and how these characteristics are perceived by users. ONPs are placed between the gum and lip, and the nicotine is absorbed in the mouth. They have a strong potential for harm reduction if smokers can switch to using them, and they are growing in popularity. One factor that could be contributing to the increase in popularity is the wide range of flavors, including mint or menthol. With recent flavor restriction policies that have gone into effect in certain areas of the United States, ONPs are now including synthetic cooling agents (WS-3) in place of the flavors. They provide a cooling sensation, but do not have a characterizing flavor, like mint or menthol, allowing them to be sold where flavor restriction policies are in place. Learning more about the flavors and cooling properties in ONPs and user preferences may help researchers guide future ONP regulation and understand how these characteristics may be used as a potential harm reduction or quit smoking tool.

Sex

All

Minimum age

21 Years

Inclusion Criteria:

* Age 21 years or older
* Willing to complete study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
* Ability to read and speak English
* Has smoked \>= 100 cigarettes
* Smokes \>= 5 cigarettes/day for past year

Exclusion Criteria:

* Use other tobacco products (including ONPs) more than 10 days per month
* Unstable or significant psychiatric conditions (past and stable conditions allowed)
* Pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test before each visit)
* History of cardiac event or distress within the past 3 months
* Currently attempting to quit all tobacco use