Clinical trial · Observational
Hematological Disorders in EHPVO Patients
A Prospective Study of the Spectrum of Haematological Disorders in Patients With Extrahepatic Portal Vein Obstruction
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study focuses on patients who have a condition called extrahepatic portal vein obstruction (EHPVO), where a blood clot blocks the portal vein outside the liver. This blockage can cause problems like an enlarged spleen, bleeding from swollen veins in the digestive system, and low blood cell counts. Many of these patients may have hidden blood disorders that increase the risk of clotting, such as myeloproliferative neoplasms (MPNs), antiphospholipid syndrome (APS), or paroxysmal nocturnal hemoglobinuria (PNH). This study will collect and analyze blood test results-such as complete blood count (CBC), liver function tests (LFTs), and clotting tests-from patients with EHPVO. The aim is to find patterns that may suggest an underlying blood disorder, even if the patient doesn't show obvious symptoms.By understanding these patterns early, doctors may be able to diagnose and treat the root causes of clotting in these patients more accurately, helping prevent complications and improve outcomes.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anemia | — | UNRESOLVED | — |
| Antiphospholipid Syndrome (APS) | — | UNRESOLVED | — |
| Extrahepatic Portal Vein Obstruction (EHPVO) | — | UNRESOLVED | — |
| Leukopenia | — | UNRESOLVED | — |
| Myeloproliferative Neoplasms (MPN) | Myeloproliferative Neoplasm | CURATED_BROADER | 0.80 |
| Paroxysmal Nocturnal Hemoglobinuria (PNH) | — | UNRESOLVED | — |
| Thrombocytopenia | — | UNRESOLVED | — |
| Thrombophilia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No intervention (Observational Study) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- EHPVO Patients
- description
- Patients diagnosed with extrahepatic portal vein obstruction (EHPVO) based on imaging (Doppler ultrasound, CT, or MRI) and with preserved liver function. This group will be assessed for hematological abnormalities, including cytopenias and coagulation disturbances, using retrospective laboratory data.
- interventionNames
- Other: No intervention (Observational Study)
Primary outcomes (2)
- measure
- Frequency of hematological disorders in EHPVO patients
- timeFrame
- Over a retrospective period from 2020 to 2024
- description
- The proportion of EHPVO Patients showing hematological disorders including cytopenias ( thrombocytopenia , anemia , leukopenia ) and coagulation disturbances based on retrospective laboratory data
- measure
- Frequency of hematological disorders in EHPVO patients
- timeFrame
- Over a retrospective period from 2020 to 2024
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years or older . Diagnosis of extra hepatic portal vein obstruction based on imaging ( Doppler, CT , MRI ) preserved liver function . Available complete medical records including CBC , LFTs and coagulation profile . Exclusion Criteria: * Patients with cirrhosis or intrahepatic portal hypertension • Incomplete or missing medical records • Patients with known hematologic malignancies or undergoing chemotherapy
References
Publications (0)
Data not yet available