Clinical trial · Interventional
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
Visual Plasticity Following Brain Lesions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260915-000001
Summary
Brief summary (as posted)
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Cortical Blindness | — | UNRESOLVED | — |
| Hemianopia | — | UNRESOLVED | — |
| Quadrantanopia | — | UNRESOLVED | — |
| Stroke | — | UNRESOLVED | — |
| Traumatic Brain Injury | — | UNRESOLVED | — |
| Visual Field Defect | — | UNRESOLVED | — |
| Visual Field Defect, Peripheral | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Perceptual learning-based training | Behavioral | — | UNRESOLVED |
| Sham Stimulation | Device | — | UNRESOLVED |
| transcranial random noise stimulation (tRNS) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- tRNS with perceptual learning-based training
- description
- Each 2-day session consists of up to three 18-minute transcranial random noise stimulation (tRNS) paired with perceptual learning-based training.
- interventionNames
- Device: transcranial random noise stimulation (tRNS)
- Behavioral: Perceptual learning-based training
- type
- SHAM_COMPARATOR
- label
- Sham with perceptual learning-based training
- description
- Each 2-day session consists of up to three 18-minute sham stimulation paired with perceptual learning-based training.
- interventionNames
- Device: Sham Stimulation
- Behavioral: Perceptual learning-based training
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
A. Stroke, brain tumor, or traumatic brain injury patients Inclusion Criteria: 1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. 3. Unilateral or bilateral focal brain damage causing loss of vision. 4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year. Exclusion Criteria: 1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results. 2. Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5. 3. Vision loss resulting from ocular disease or disorder. B. Healthy volunteers (age-matched controls): Inclusion Criteria: 1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. Exclusion Criteria: 1. Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results. 2. Previous head injury. 3. Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.
References
Publications (0)
Data not yet available