Clinical trial · Observational
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
THE REAL-LIFE BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS: A COMPARATIVE PROPENSITY-MATCHED ANALYSIS FROM A GLOBAL MULTICENTER DATABASE (THE ESCAPE STUDY)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction. In recent years, a potential association between EoE and esophageal cancer (EC) has been proposed, though evidence remains inconsistent and may be influenced by overlapping conditions like gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE). The purpose of this study was to determine whether patients with EoE are at increased risk of developing esophageal cancer, and to clarify whether any observed risk is intrinsic to EoE or instead related to coexisting GERD or BE. The main research question was: Is eosinophilic esophagitis independently associated with an increased risk of esophageal cancer, or is this risk mediated by overlapping conditions such as GERD or Barrett's esophagus? To address this, we conducted a retrospective, multicenter cohort study using real-world data from TriNetX, a global federated health research network aggregating electronic medical records from approximately 100 million patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Eosinophilic Esophagitis (EoE) | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- A) primary cohort of EoE patients
- description
- The primary cohort of the main analysis was built to include all eosinophilic esophagitis (EoE) patients, therefore implementing the ICD-10 code specific for the disease (K20.0). In order not to include other eosinophilic gastrointestinal disorders (EGIDs) primary cohort was built excluding the following ICD-10(ICD-9) codes: * K52.81: Eosinophilic Gastritis or Gastroenteritis * K52.82: Eosinophilic Colitis * K558.4: Eosinophilic gastroenteritis and colitis Following diagnosis were excluded if happened on or before the index event: * ICD-10-K22.7 Barrett Esophagus * ICD-10-K22.71 Barrett Esophagus with dysplasia * ICD-10-K22.711 Barrett Esophagus with high-grade dysplasia * ICD-10-K22.719 Barrett Esophagus with dysplasia, unspecified * ICD-10-K22.710 Barrett Esophagus with low-grade dysplasia * ICD-10-K22.1 Ulcer of the esophagus * ICD-10-K22.10 Ulcer of the esophagus without bleeding * ICD-10-K22.11 Ulcer of the esophagus with bleeding * ICD-10-C15 Esophageal cancer
- label
- Cohort B: Pure EoE without BE/GERD
- description
- The secondary cohort (Cohort B) of the main analysis was built to include all eosinophilic esophagitis (EoE) patients, therefore implementing the ICD-10 code specific for the disease (K20.0). In order not to include other eosinophilic gastrointestinal disorders (EGIDs) leading to confounding clinical profiles, this primary cohort was built excluding the following ICD-10(ICD-9) codes: * K52.81: Eosinophilic Gastritis or Gastroenteritis * K52.82: Eosinophilic Colitis * K558.4: Eosinophilic gastroenteritis and colitis To eliminate the confounding effect of BE and objective GERD was built with the exclusion from cohort A of the following diagnosis: * ICD-10-K22.7 Barrett Esophagus * ICD-10-K22.71 Barrett Esophagus with dysplasia * ICD-10-K22.711 Barrett Esophagus with high-grade dysplasia * ICD-10-K22.719 Barrett Esophagus with dysplasia, unspecified * ICD-10-K22.710 Barrett Esophagus with low-grade dysplasia * ICD-10-K22.1 Ulcer of the esophagus * ICD-10-K22.11 Ulcer of the esophagus with bleeding
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * EoE diagnosed patients according to ICD-10 code K20 Exclusion Criteria: * Patients diagnosed with other EGIDs (- K52.81: Eosinophilic Gastritis or Gastroenteritis * K52.82: Eosinophilic Colitis * K558.4: Eosinophilic gastroenteritis and colitis)
References
Publications (0)
Data not yet available