68Ga-NYM096 PET/ CT for the Detection of Clear Cell Renal Cell Carcinoma in Presurgical Patients With Renal Masses

Inclusion Criteria :

1. Age: ≥18 years;
2. Gender: No restriction;
3. Renal mass (solitary or multiple) with a maximum diameter ≥1 cm, confirmed by conventional imaging (ultrasound, non-contrast CT, contrast-enhanced CT, or MRI);
4. Scheduled for renal mass resection (partial or total nephrectomy, via open, laparoscopic, or robot-assisted techniques) within 1 month;
5. Life Expectancy:

   * At least 3 months, as assessed by a clinician;
   * ECOG Performance Status: 0-2;
6. Informed Consent: Provision of written informed consent;
7. Compliance: Willing and able to adhere to study procedures.

Exclusion Criteria :

1. Surgical Contraindications:

   * High anesthesia risk (ASA class ≥IV);
   * Severe cardiopulmonary dysfunction (NYHA class III-IV or FEV1 \<50%);
   * Active bleeding or coagulation disorders (INR \>1.5, platelets \<80×10⁹/L).
2. Pregnancy/Lactation:

   * Pregnant (positive blood/urine HCG) or breastfeeding women;
   * childbearing potential without effective contraception.
3. Other Contraindications:

   * Claustrophobia;
   * Weight \>150 kg ;
   * Alcohol allergy.
4. Any condition deemed by the investigator to interfere with study results or increase participant risk.