A Randomized, Two-cohort, Prospective Phase II Clinical Study of the Second-line Treatment of Advanced Biliary System Tumors With Liposomal Irinotecan (II) Combination Regimen

Inclusion Criteria:

* The patients voluntarily joined the study and signed the informed consent;
* Histologically or cell line confirmed advanced biliary system malignancies, including intrahepatic, extrahepatic, and gallbladder cancers;
* Previous first-line combination therapy failed;
* At least one measurable lesion meets the RECIST v1.1 criteria
* ECOG PS：0\~1；
* Expected survival ≥12 weeks;
* Essential organ and hematological function;
* Patients need contraception;

Exclusion Criteria:

* The patient had previously received irinotecan, 5-Fu, and antiangiogenic agents;
* Patients had active malignancies other than BTC within 5 years or at the same time.
* Clinical symptoms or diseases of the heart that are not well controlled;
* Patients with hypertension who cannot be reduced to the normal range by antihypertensive medication (systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg);
* Any clinically significant gastrointestinal disorder, including bleeding, inflammation, occlusion, or diarrhea \> grade 2;
* A thrombotic or embolic event occurred within 6 months prior to the start of the study therapy;
* Use of strong CYP3A4/CYP2C19 inducers including rifampicin (and its analogiaries) and hypericum perforatum or strong CYP3A4/CYP2C19 inhibitors and/or strong UGT1A inhibitors within 14 days prior to signing the informed consent;
* Known allergy to the study drug;
* An uncontrolled infection occurs during screening;
* Patients with congenital or acquired immune deficiency (e.g., HIV);
* Have a history of brain metastases or have developed brain metastases;