Clinical trial · Observational
Parathyroid Adenoma Detection With Rubidium-82 Imaging
Parathyroid Adenoma Detection With Rubidium Chloride Imaging: A Proof-of-Concept Study
NCT07099404CI-TRIAL-00094029PARAGONnot yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Assess the uptake of rubidium-82 in parathyroid adenomas.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hyperparathyroidism, Primary | — | UNRESOLVED | — |
| Parathyroid Adenomas | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PET/CT imaging with rubidium-82 | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Uptake pattern of rubidium-82 in parathyroid adenomas
- timeFrame
- 3 months
- description
- Rudibium-82 uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values.
Secondary outcomes (1)
- measure
- Comparison between the uptakes of rubidium-82 and 18F-fluorocholine in patients with parathyroid adenomas
- timeFrame
- 3 months
- description
- Radioactive tracer uptake will be compared between Rudibium-82 and 18F-Fluorocholine. Uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age ≥ 18y 2. Ability to undergo imaging logistics 3. Ability to provide informed consent 4. Biochemical evidence of primary hyperparathyroidism 5. Documented parathyroid adenoma on prior 18F-fluorocholine imaging Exclusion Criteria: 1. Normocalcemic primary hyperparathyroidism 2. Breastfeeding or pregnancy 3. Claustrophobia or inability to undergo imaging logistics 4. Any other history, condition, therapy, or uncontrolled intercurrent illness, which could in the opinion of the investigator affect compliance with study requirements or which would make the participant unsuitable for this study
References
Publications (0)
Data not yet available
No reference posted for this study.