Clinical trial · Interventional
The Lung Health Check Pilot
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to test if it is feasible to introduce lung cancer screening in Ireland. People within a certain age group, who smoke or who smoked in the past, are at a greater risk of developing lung cancer. They can also develop chronic lung conditions that can affect their long-term health. In Ireland, about 2,690 people are diagnosed with Lung Cancer every year. Unfortunately, 2 out of every 3 people diagnosed with lung cancer die per year. The goal of this study is to try to screen for lung cancer in people before they have symptoms associated with the disease. We aim to do this by selecting people based on their age, whether they have smoked in the past or currently smoke as well as other relevant factors. People who take part in this study will have an assessment of how their lungs work and a low-dose CT scan. This is called a lung health check. The goal of the low-dose CT scan is to pick up lung cancer before it becomes symptomatic, and at an earlier stage. This scan uses a very low dose of radiation. Unfortunately, without early detection, such as is the goal of this trial, 8 out of 10 people who go on to develop lung cancer will have advanced lung cancer when it is discovered, where outcomes tend to be poor. The earlier detection of lung cancer has a greater potential for treatment. Current international recommendations suggest carrying out these scans in the community rather than in a hospital. Therefore, we aim to deliver these lung health checks using a mobile unit in the community. This study aims to test if we will successfully pick up lung cancer earlier by doing community-based 'lung health check's using mobile units in North Dublin and the North East, among people of a certain age and smoking history.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low dose CT | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Lung Health Check
- description
- In this arm, consented participants will undergo a 'Lung Health Check' which incorporates a respiratory disease assessment, smoking cessation, low-dose CT and collection of biospecimens for translational analyses.
- interventionNames
- Diagnostic Test: Low dose CT
Primary outcomes (2)
- measure
- i) The proportion of high-risk eligible participants aged 55-74 years who participate in a community-based lung health check ii)The proportion of individuals who consent to undergo telephone assessment
- timeFrame
- 1 year
- description
- i) Number of eligible participants who attend the LHC pilot after GP invitation/Number of high-risk participants invited via GP letter to the LHC pilot ii) Number of participants who consent to undergo telephone assessment/number of participants invite via GP letter to LHC pilot
- measure
- The proportion of individuals who consent to undergo telephone assessment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 55 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: 1. 55 - 74 years of age 2. Current or former smokers * Current: \>100 cigarettes in lifetime and/or currently tobacco smoking * Former: \>100 cigarettes in lifetime and/or no tobacco smoking \>= 28 days 3. Referred from a GP for the LHC pilot 4. PLCOM2012 ≥ 1.51% or LLPv2 ≥2.5% (Lung Cancer Risk Scores) * Prostate Lung Cancer Colorectal Ovarian (PLCO) \& Liverpool Lung Project Version 2 (LLPv2) Exclusion Criteria: 1. Participant-reported history of chest CT in the last 12 months 2. Inability to undergo non-contrast CT (e.g. \>200 kg body weight, inability to lie flat) 3. Participant reported known diagnosis of other advanced stage cancers 4. Participant reported diagnosis of lung cancer of any stage in the last 5 years 5. Likely non-compliance with study procedures, as determined by the participant i) Unable to provide informed consent ii) Inability to attend study visits 6. Nursing home residents -
References
Publications (1)
- DERIVEDO Reilly D, Roche S, Noonan C, O'Shea J, Toomey S, Hennessy BT, Fitzmaurice GJ, Egan K, Dunne J, Dowling CM, Counihan I, O'Brien E, Sulaiman I, Morgan R, Jacob B, Baird AM, Cotter S, Bailey D, Maguire G, Bennett K, Sorensen J, Healy NA, Ryan J, Redmond P, Ryan DJ, Naidoo J. Lung Health Check pilot: Ireland's flagship lung cancer screening trial. BMJ Open Respir Res. 2025 Sep 10;12(1):e003035. doi: 10.1136/bmjresp-2024-003035. PMID 40935563