Clinical trial · Interventional
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing hepatectomy. A retrospective analysis of 80 liver cancer patients was conducted, categorized by analgesic adequacy, pain recovery, and POCD incidence: adequate vs. inadequate analgesia (n=50 vs. n=30), favorable vs. delayed pain recovery (n=36 vs. n=44), and POCD vs. non-POCD (n=42 vs. n=38). Based on these results, a prospective study (April 2024-April 2025) enrolled patients scheduled for elective hepatectomy, assigned to the GA group (n=59) or GEA group (n=47). Primary outcomes included intraoperative analgesic consumption, postoperative VAS pain scores, MoCA cognitive scores, hospital stay length, and adverse event rates.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia Techniques | — | UNRESOLVED | — |
| Cognitive Dysfunction | — | UNRESOLVED | — |
| Epidural-general Anesthesia | — | UNRESOLVED | — |
| Hepatectomy | — | UNRESOLVED | — |
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Postoperative Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| General Anesthesia (GA) group | Drug | — | UNRESOLVED |
| General-Epidural Anesthesia (GEA) group | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- general anesthesia group
- description
- In the General Anesthesia (GA) group (n = 59), patients received combined intravenous-inhalation general anesthesia. Anesthesia induction was performed using propofol and remifentanil, followed by maintenance with sevoflurane to ensure adequate anesthetic depth and hemodynamic stability throughout the procedure.
- interventionNames
- Drug: General Anesthesia (GA) group
- type
- EXPERIMENTAL
- label
- General-Epidural Anesthesia group
- description
- In the General-Epidural Anesthesia (GEA) group (n = 47), patients received the same general anesthesia protocol as the GA group, in addition to epidural anesthesia. An epidural catheter was placed preoperatively at the T7-T9 vertebral level using a midline approach under strict aseptic conditions. Following successful catheterization and confirmation of proper placement, a continuous intraoperative infusion of 0.25% ropivacaine was administered via the epidural route to provide segmental analgesia and reduce intraoperative opioid requirements.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
* Inclusion Criteria: * Histologically or radiologically confirmed primary liver cancer (HCC or cholangiocarcinoma) * Scheduled for elective open or laparoscopic radical hepatectomy * Age 18-75 years * ASA Physical Status I-III * Child-Pugh class A or B liver function * Normal preoperative MoCA score (≥26) * Willing to participate and provide informed consent * Exclusion Criteria: * Severe cardiovascular, pulmonary or renal disease (ASA IV/V) * Chronic pain disorders or preoperative opioid use (\>3 months) * Known neurologic/psychiatric conditions (dementia, stroke, epilepsy) * Concurrent major procedures (e.g., vascular resection) * Intraoperative conversion to palliative surgery * Massive intraoperative hemorrhage (\>2000 mL) * Coagulopathy (INR \>1.5 or platelets \<50×10⁹/L) * Spinal abnormalities precluding epidural catheterization * Pregnancy or lactation * Allergy to local anesthetics or study medications
References
Publications (0)
Data not yet available