An Exploratory Study on NK Cell-assisted Prevention of Bone Marrow Suppression During Chemotherapy for Ovarian Cancer

Inclusion Criteria:

* Age 18-70 years old (≥18, ≤70);
* Confirmed by pathology of high grade serous ovarian cancer, high level of endometrial carcinoma, and/or primary peritoneal carcinoma fallopian tube carcinoma epithelial ovarian cancer;
* ECOG score: 0-1;
* before, during, and after treatment of blood specimen can obtain, and the participants agreed to expand blood samples to central laboratory for the trial research purposes.;
* Expectations alive at least 3 months;
* Laboratory examination indexes meet the following requirements
* (1) renal function: Cr ULN or less (upper limit of normal) x 1.5, endogenous creatinine clearance rate (Ccr) or 60 ml/min;
* (2) the liver function: the total bilirubin ULN x 1.5 or less; ALT and AST≤ULN×2.5; (If there is intrahepatic cholangiocarcinoma or liver metastasis, the total bilirubin level should be less than 3 times the upper limit of normal, and the aminotransferase level should be less than 5 times the upper limit of normal); The neutrophilic granulocyte count
* Women of childbearing age agreed to during the study and research within 6 months after the end of contraception, And non-lactating patients;
* Participants can understand the research situation and voluntarily signed informed consent. No serious complications such as active digestive tract hemorrhage, perforation, jaundice, gastrointestinal obstruction, non cancerous fever \> 38 ℃;
* Expected, adherence to the good curative effect and adverse reaction will be effected according to the plan calls for follow-up

Exclusion Criteria:

* Patients had received drugs that were in other clinical trials or other cellular immunotherapies within 28 days before the screening period;
* Patients with other malignant tumours in the past five years.;
* Acute illness is ongoing, or in the past 2 years with severe disease, such as active infection, cardiovascular disease or fever patients heart function (grade III or IV level), mental health problems (such as alcohol, drugs).;
* Immunodeficiency disease, including HIV positive or suffering from other acquired and congenital immunodeficiency disease;
* Organ transplantation, organ transplantation or organ failure patients undergoing immunosuppressive medication or long-term use of immunosuppressive drugs patients;
* Move/vein thrombosis incidents happened in 6 months, such as cerebrovascular accident (including transient ischemic attack), deep vein thrombosis and pulmonary embolism;
* In patients with known to METR NK preparation any component of the final product, including the human serum albumin;
* Breastfeeding during screening serum or urine pregnancy test was positive in female;
* subjects suffering from mental illness, including major depression, mania, epilepsy, dementia, etc;
* Researchers say the other condition that doesn't fit into the group.