Clinical trial · Observational
Relationship Between Serum Xanthine Oxidase Levels and Seborrheic Keratosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This observational study aims to examine the relationship between serum xanthine oxidase (XO) levels and seborrheic keratosis (SK), a common benign skin tumor, especially in middle-aged and older adults. The pathogenesis of SK remains unclear, but oxidative stress is believed to play a role. XO is an enzyme that contributes to the production of reactive oxygen species (ROS), which can cause oxidative damage in the skin. A total of 80 participants will be included in the study, consisting of 40 patients diagnosed with SK and 40 healthy individuals as controls. Each participant will undergo clinical and dermoscopic examination, followed by blood sampling to measure serum XO levels using ELISA. The study will be conducted at the Dermatology and Venereology Clinic of Prof. dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara Hospital from October 2023 to June 2024. This study has been reviewed and approved by the Ethics Committee of the Faculty of Medicine, Universitas Sumatera Utara.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oxidative Stress | — | UNRESOLVED | — |
| Seborrheic Keratosis (SK) | Seborrheic Keratosis | ONTOLOGY_EXACT | 0.85 |
| Skin Aging | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Serum Xanthine Oxidase Level Assessment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Seborrheic Keratosis Group
- description
- This group includes 40 participants diagnosed with seborrheic keratosis through clinical and dermoscopic examination. Venous blood was collected to measure serum xanthine oxidase (XO) levels using ELISA. Participants were between 18 and 50 years old and had no underlying systemic diseases. This group represents the case population in this observational case-control study.
- interventionNames
- Other: Serum Xanthine Oxidase Level Assessment
- label
- Control Group
- description
- This group includes 40 healthy participants without seborrheic keratosis or other hyperpigmented skin lesions. They were age- and sex-matched to the case group. Blood samples were collected to determine serum XO levels using the same ELISA protocol. These individuals served as the control group for comparison of XO levels.
- interventionNames
- Other: Serum Xanthine Oxidase Level Assessment
Primary outcomes (1)
- measure
- Serum Xanthine Oxidase Concentration Measured by ELISA in Patients With and Without Seborrheic Keratosis
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 18 to 50 years * Willing to participate and sign informed consent * Able to undergo dermatologic and dermoscopic examination * For case group: diagnosed with seborrheic keratosis * For control group: no clinical or dermoscopic evidence of seborrheic keratosis Exclusion Criteria: * History or presence of other hyperpigmentation skin lesions (e.g., lentigo solaris) * Diagnosed with systemic diseases such as diabetes mellitus, cardiovascular disease, hepatitis, HIV/AIDS, gout, or renal impairment * Taking medications that affect oxidative stress biomarkers * Pregnant or breastfeeding women
References
Publications (0)
Data not yet available