Clinical trial · Observational
Anastomotic Leakage in Colorectal Cancer Surgery in Syria
Anastomotic Leakage in Colorectal Cancer Surgery in Syria: Risk Factors and Improvements Following Guideline Implementation - A Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Anastomotic leakage is a serious complication of colorectal cancer surgery, particularly in resource-limited and conflict-affected settings. This retrospective cohort study conducted at Damascus Hospital, Syria, evaluated patient and procedure related risk factors for anastomotic leakage following elective sigmoid colon and rectal resections. An initial cohort (January 2016-March 2024) identified modifiable risk factors that informed updates to institutional preoperative and perioperative guidelines. A follow-up cohort (April 2024-October 2025) was subsequently analyzed to assess outcomes after guideline implementation. The study demonstrates that targeted optimization, especially correction of hypoalbuminemia and improved perioperative management was associated with reduced anastomotic leakage and postoperative mortality, highlighting the value of context-specific, evidence-based guideline changes in low-resource surgical settings.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leakage in Colon Surgery | — | UNRESOLVED | — |
| Anastomotic Leak Large Intestine | — | UNRESOLVED | — |
| Anastomotic Leak Rectum | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- The First Cohort
- description
- Pre-guideline cohort - patients treated before the implementation of the updated hospital guidelines (January 2016 - March 2024).
- label
- The follow-up cohort
- description
- Post-guideline cohort - patients treated after the implementation of the updated guidelines (April 2024 - October 2025).
Primary outcomes (1)
- measure
- Correlation between preoperative serum albumin level and incidence of anastomotic leakage following colorectal cancer surgery
- timeFrame
- Within 30 days post-surgery
- description
- Preoperative serum albumin concentration measured in g/dL using routine hospital laboratory biochemical analysis will be correlated with the incidence of anastomotic leakage. Anastomotic leakage will be assessed as a binary outcome (yes/no) based on clinical findings, radiological imaging (contrast-enhanced CT), and/or intraoperative confirmation within the postoperative follow-up period.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients who underwent colorectal cancer surgery for tumor-related indications. Exclusion Criteria: * Emergency cases * Non-tumor related colorectal surgeries
References
Publications (0)
Data not yet available