Clinical trial · Observational
Real-world Outcomes Among Patients With Melanoma Treated With Neoadjuvant Nivolumab+Relatlimab or Nivolumab+Ipilimumab
Real-world Outcomes Among Patients With Melanoma Treated With Neoadjuvant Nivolumab+Relatlimab (Nivo+Rela) or Nivolumab+Ipilimumab (Nivo+Ipi)
NCT07091695CI-TRIAL-00097140completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to understand the characteristics of adults diagnosed with with clinically palpable stage III resectable melanoma, the associated treatment patterns for their disease, and outcomes associated with the real-world use of neoadjuvant nivolumab+relatlimab or nivolumab+ipilimumab
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Melanoma | Melanoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nivolumab + ipilimumab | Biological | Ipilimumab/Nivolumab Regimen | ALIAS |
| Nivolumab + relatlimab | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Participants receiving nivolumab + relatlimab treatment
- interventionNames
- Biological: Nivolumab + relatlimab
- label
- Participants receiving nivolumab + ipilimumab treatment
- interventionNames
- Biological: Nivolumab + ipilimumab
Primary outcomes (21)
- measure
- Participant baseline demographics
- timeFrame
- Baseline
- measure
- Participant baseline clinical characteristics
- timeFrame
- Baseline
- measure
- Participant treatment history
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participants at least 18 years old at diagnosis of clinically palpable stage III resectable melanoma * Participants treated with nivolumab+relatimab (nivo+rela) or nivolumab+ipilimumab (nivo+ipi) in the neoadjuvant setting * Participants with at least 6 months of follow-up from initiation of neoadjuvant therapy, unless deceased prior to 6 months of follow-up Exclusion Criteria: * Participants received nivo+rela or nivo+ipi for clinically palpable stage III resectable melanoma as part of a therapeutic clinical trial * Participants had history of diagnosis of any malignancy (except for non-melanoma skin cancer) in the last 2 years. * Participants received adjuvant nivo+rela or adjuvant nivo+ipi after neoadjuvant nivo+ipi * Participants received adjuvant nivo+ipi after neoadjuvant nivo+rela * Participants received any systemic therapy prior to the initiation of neoadjuvant nivo+rela or nivo+ipi
References
Publications (0)
Data not yet available
No reference posted for this study.