Clinical Study to Evaluate the Efficacy and Safety of Nab-Paclitaxel Combined With Cisplatin and Sintilimab in Neoadjuvant Treatment of Locally Advanced Cervical Cancer

Inclusion Criteria:

* Aged ≥ 18 years and ≤ 70 years;
* Cervical cancer with pathological types being squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma;
* Staged IB3 or IIA2 according to the FIGO 2018 staging system, as assessed by the investigator;
* ECOG performance status of 0-2, or KPS score ≥ 70;
* Expected survival time of more than 3 months;
* Having at least one measurable lesion in accordance with RECIST 1.1;
* Laboratory test results meeting the following criteria without drug intervention:

  1. Hemoglobin ≥ 90 g/dl, neutrophil count ≥ 1.5 × 10⁹/L, platelet count ≥ 100 × 10⁹/L;
  2. Creatinine ≤ 1.5 times the upper limit of normal range;
  3. Total bilirubin, alanine transaminase (ALT), and aspartate transaminase (AST) \< 2 times the upper limit of normal;
* Postmenopausal, or reproductive-aged women who meet all the following conditions: non-lactating, not pregnant, and able to use effective contraceptive measures during the study treatment period;
* Voluntarily participating in this study and signing the informed consent form.

Exclusion Criteria:

* Participated in other clinical trials within 30 days before receiving the first dose of chemotherapy drugs or during the treatment period.
* Previously received any other anti-tumor treatment for cervical cancer.
* Non-HPV-related cervical cancer.
* Needing to receive other anti-tumor treatments during the study treatment period.
* Patients with known allergies to the active ingredients of the study drugs or their excipients.
* Diagnosed with other malignant tumors in the past 5 years (except those judged to be cured by the investigator).
* Active infections requiring systemic treatment.
* Positive for human immunodeficiency virus (HIV) antibody.
* Positive for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody.
* Peripheral neuropathy with a grade of ≥ 2 according to the NCI-CTCAE (Version 5.0).
* Concurrent diseases or abnormal test results that interfere with the subject's ability to receive anti-tumor treatment as judged by the investigator, such as the estimated inability of the subject to tolerate at least 2 cycles of neoadjuvant chemotherapy plus surgery or concurrent chemoradiotherapy, etc.

Participation in this study is deemed not conducive to the maximum benefit of the subject as judged by the investigator.