Phase I/II Study of SCTB39G in Advanced Solid Tumours

Inclusion Criteria:

* 1.Voluntarily sign the informed consent form (ICF);
* 2.Male or female, ≥ 18 years and ≤ 70 years old;
* 3.Survival duration more than 3 months;
* 4.ECOG score ≤ 1 point;
* 5.histologically or cytologically confirmed diagnosis of advanced malignant solid tumour；
* 6.At least one measurable tumor lession according to RECIST v1.1;
* 7.Adequate organ and bone marrow function.

Exclusion Criteria:

* 1.Has participated in another clinical study within 4 weeks prior to the first dose;
* 2.Other malignancies diagnosed within 1 years prior to the enrollment;
* 3\. Participants with brainstem, meningeal, spinal metastases, or compression; active central nervous system metastases;
* 4.NSCLC at high risk of bleeding; Obvious invasion of tumor into adjacent organs of esophageal lesions leads to high risk of bleeding or fistula,or participants after endotracheal stent implantation;
* 5.Participants with portal hypertension due to portal vein tumor thrombus at risk of bleeding;
* 6.Presence of pleural effusion, peritoneal effusion, or ascites;
* 7.Received chemotherapy, immunotherapy, biologic therapy, or other antitumor treatments within 4 weeks before enrollment
* 8.History of permanent discontinuation of immunotherapy due to immune-related toxicity or occurrence of ≥ Grade 3 irAEs;
* 9.Presence of any active autoimmune disease or a history of autoimmune disease with an expected recurrence;
* 10.History of severe allergies, severe drug allergies (including unapproved investigational drugs);
* 11.History of organ transplantation or stem cell transplantation;
* 12.Need for immunosuppressive drugs within 2 weeks prior to enrollment or anticipated during the study;
* 13.Pregnant or breastfeeding female.