Clinical trial · Interventional
Use of Nitrous Oxide During Office Hysteroscopy
Nitrous Oxide During Office Hysteroscopy for Reducing Pain and Anxiety
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: * Does it reduce pain during the procedure? * Does it increase the success rate? * Does it improve patient satisfaction? * Does it reduce anxiety? * Which populations benefit more (e.g., parity, menopausal status, number of previous surgeries, type and duration of procedure, and type of device)? Participants will be asked about their pain levels during the procedure, as well as their anxiety levels. All responses will be recorded. Written informed consent will be obtained prior to initiation.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abnormal Uterine Bleeding | — | UNRESOLVED | — |
| Endometrial Polyps | — | UNRESOLVED | — |
| Intrauterine Adhesions | — | UNRESOLVED | — |
| Postmenopausal Bleeding | — | UNRESOLVED | — |
| Retained Products of Conception | — | UNRESOLVED | — |
| Uterine Fibroids | Uterine Corpus Leiomyoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| inhalation of ambient air during office hysteroscopy | Procedure | — | UNRESOLVED |
| Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- treatment- inhaled nitrous oxide
- description
- Participants in the Nitrous Oxide group will inhale a fixed 50:50 mixture of nitrous oxide (N₂O) and oxygen (O₂), starting one minute prior to the procedure and continuing throughout its duration. The gas is administered via a self-administered demand-valve face mask connected to the Blendox system (Ambulanc®, Italy).
- interventionNames
- Procedure: Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy
- type
- PLACEBO_COMPARATOR
- label
- Inhaled ambient air control group
- description
- Participants in the control group will inhale ambient air starting one minute prior to the procedure and will continue inhalation throughout its duration. The ambient air is administered via a self-administered demand-valve face mask connected to the Blendox system (Ambulanc®, Italy).
- interventionNames
- Procedure: inhalation of ambient air during office hysteroscopy
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Women aged ≥18 years Scheduled to undergo operative office hysteroscopy for clinical indications Exclusion Criteria: Any contraindications to N₂O, including: Pneumothorax Significant chronic obstructive pulmonary disease (COPD) Upper airway obstruction Bowel obstruction Middle ear pathology (e.g., recent ear surgery or active ear infection) Severe recent intraocular gas injection Severe vitamin B12 deficiency Known hypersensitivity to N₂O Women who will decline randomization or unable to provide informed consent.
References
Publications (3)
- RESULTLikis FE, Andrews JC, Collins MR, Lewis RM, Seroogy JJ, Starr SA, Walden RR, McPheeters ML. Nitrous oxide for the management of labor pain: a systematic review. Anesth Analg. 2014 Jan;118(1):153-67. doi: 10.1213/ANE.0b013e3182a7f73c. PMID 24356165
- RESULTBuhre W, Disma N, Hendrickx J, DeHert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. Br J Anaesth. 2019 May;122(5):587-604. doi: 10.1016/j.bja.2019.01.023. Epub 2019 Feb 22. PMID 30916011
- DERIVEDRazdolsky S, Yaniv-Tamir R, Raz M, Kolp-Asis S, Katz T, Elbaz L, Tzur T. Nitrous Oxide for Pain Management in Office Hysteroscopy: A Randomized Placebo-Controlled Trial. Obstet Gynecol. 2026 Jul 1;148(1):71-79. doi: 10.1097/AOG.0000000000006282. Epub 2026 Apr 9. PMID 41955620