Clinical trial · Observational
Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer
Identification of Paraneoplastic and Intratumoral Microplastics in Colorectal Cancer and Their Association Analysis With Macrogenomics and Metabolomics
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer (MSI-H) | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Microplastic Exposure | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| exposure to microplastic | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- the colorectal cancer group
- description
- patients diagnosed with colorectal cancer
- interventionNames
- Other: exposure to microplastic
Primary outcomes (1)
- measure
- genomics
- timeFrame
- Blood specimens were obtained within one week prior to surgery.
- description
- Genomics was tested by preoperative blood specimens.
Secondary outcomes (1)
- measure
- metabolomics
- timeFrame
- Blood specimens were obtained within one week prior to surgery.
- description
- Metabolomics was tested by preoperative blood specimens.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma. * Undergoing elective radical colorectal cancer resection at the study hospital. * No prior chemotherapy, radiotherapy, or targeted therapy before surgery. * Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery. * Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Patients with a history of other malignancies within the past 5 years. * Emergency surgery due to obstruction, perforation, or bleeding. * Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis. * Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis). * Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection. * Pregnant or breastfeeding women. * Refusal or inability to provide informed consent.
References
Publications (0)
Data not yet available